See D M, Tilles J G
Department of Medicine School of Medicine, University of California at Irvine Orange 92668, USA.
Immunol Invest. 1996 Jan-Mar;25(1-2):153-64. doi: 10.3109/08820139609059298.
Thirty patients who fulfilled clinical criteria defined by the CDC for Chronic Fatigue Syndrome were treated with alfa 2a interferon or placebo in a double-blind crossover study. Outcome was evaluated by Natural Killer (NK) cell function, lymphocyte proliferation to mitogens and soluble antigens, CD4/CD8 counts and a 10 item Quality of Life (QOL) survey. Although mean NK function rose from 87.8 +/- 19.6 to 129.3 +/- 20.7 lytic untis (LU; p < .05) with 12 weeks of interferon therapy, there was no significant change in the other immunologic parameters or QOL scores. When the 26 patients who completed the study were stratified according to their baseline NK function and lymphocyte proliferation, 4 groups were identified: 3 patients had normal NK cell function and lymphocyte proliferation when compared to normal, healthy controls, 9 had isolated deficiency in lymphocyte proliferation, 7 had diminished NK function only, and 7 had abnormalities for both parameters. QOL scores were not significantly different for the four groups at baseline. After 12 weeks of interferon therapy, QOL score significantly improved in each of the seven patients with isolated NK cell dysfunction (mean score, 16.3 +/- 7.9) compared to baseline (39.7 +/- 12.1; p < .05). In these patients the mean NK function increased from 35.1 +/- 11.7 to 91.5 +/- 22.7 LU (p < .01). Significant improvement was not recorded for QOL in the other three groups. Thus, therapy with alpha interferon has a significant effect on the QOL of that subgroup of patients with CFS manifesting an isolated decrease in NK function.
在一项双盲交叉研究中，30名符合美国疾病控制与预防中心（CDC）定义的慢性疲劳综合征临床标准的患者接受了α2a干扰素或安慰剂治疗。通过自然杀伤（NK）细胞功能、淋巴细胞对有丝分裂原和可溶性抗原的增殖反应、CD4/CD8计数以及一项包含10项内容的生活质量（QOL）调查来评估结果。尽管接受12周干扰素治疗后，平均NK功能从87.8±19.6溶细胞单位（LU）升至129.3±20.7 LU（p<.05），但其他免疫参数或QOL评分并无显著变化。当根据基线NK功能和淋巴细胞增殖情况对完成研究的26名患者进行分层时，可分为4组：与正常健康对照相比，3名患者的NK细胞功能和淋巴细胞增殖正常，9名患者仅有淋巴细胞增殖缺陷，7名患者仅NK功能降低，7名患者这两个参数均异常。四组患者在基线时的QOL评分无显著差异。干扰素治疗12周后，7名单纯NK细胞功能障碍患者（平均评分，16.3±7.9）的QOL评分与基线（39.7±12.1；p<.05）相比均显著改善。这些患者的平均NK功能从35.1±11.7 LU增至91.5±22.7 LU（p<.01）。其他三组患者的QOL未记录到显著改善。因此，α干扰素治疗对慢性疲劳综合征中表现为单纯NK功能降低的亚组患者的生活质量有显著影响。
