Kokunin V A, Tkanchuk A M, Delevaia V P, Gulyĭ M F
Ukr Biokhim Zh. 1977 Jan-Feb;49(1):83-6.
The content of free nucleotides and exchangeability of adenine nucleotides were studied in the liver of 1- and 18-month cocks. It is established that adenine nucleotides in the young cocks liver account for 40%, uridine nucleotides for 29%, cytidine nucleotides for 13% of the total amount of nucleotides. These ratios are maintained with age but the amount of adenine nucleotides decreases by 35% and that of uridine nucleotides by 22%. Against a background of a relatively constant level of adenine and uridine nucleotides the content of cytidine and guanine nucleotides varies synchronously within wide ranges, which can evidence for the presence of a common mechanism of regulating synthesis of these metabolites. A direct correlation is detected between the amount of adenine nucleotides and their specific radioactivity. This is due to a higher intensity of synthetic processes in young cocks. The inverse correlation is observed in adult cocks, that results from the effect of "label dilution".
研究了1月龄和18月龄公鸡肝脏中游离核苷酸的含量及腺嘌呤核苷酸的交换性。结果表明，幼龄公鸡肝脏中腺嘌呤核苷酸占核苷酸总量的40%，尿苷核苷酸占29%，胞苷核苷酸占13%。这些比例随年龄保持不变，但腺嘌呤核苷酸的量减少了35%，尿苷核苷酸的量减少了22%。在腺嘌呤和尿苷核苷酸水平相对恒定的背景下，胞苷和鸟嘌呤核苷酸的含量在很宽的范围内同步变化，这可能证明存在调节这些代谢物合成的共同机制。腺嘌呤核苷酸的量与其比放射性之间存在直接相关性。这是由于幼龄公鸡合成过程的强度较高。在成年公鸡中观察到负相关，这是“标记稀释”效应的结果。
