• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Haemophilus ducreyi hemolysin acts as a contact cytotoxin and damages human foreskin fibroblasts in cell culture.杜克雷嗜血杆菌溶血素作为一种接触性细胞毒素，在细胞培养中会损伤人包皮成纤维细胞。
Infect Immun. 1996 Jun;64(6):2349-52. doi: 10.1128/iai.64.6.2349-2352.1996.
2
Target cell range of Haemophilus ducreyi hemolysin and its involvement in invasion of human epithelial cells.杜克雷嗜血杆菌溶血素的靶细胞范围及其在侵袭人上皮细胞中的作用。
Infect Immun. 1999 Aug;67(8):3740-9. doi: 10.1128/IAI.67.8.3740-3749.1999.
3
An isogenic haemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effects on human foreskin fibroblasts.杜克雷嗜血杆菌的同基因溶血素缺陷型突变体缺乏对人包皮成纤维细胞产生细胞病变效应的能力。
Mol Microbiol. 1996 Jul;21(1):13-9. doi: 10.1046/j.1365-2958.1996.00615.x.
4
Characterization of the hemolytic activity of Haemophilus ducreyi.杜克雷嗜血杆菌溶血活性的鉴定
Infect Immun. 1995 Nov;63(11):4409-16. doi: 10.1128/iai.63.11.4409-4416.1995.
5
The role of Haemophilus ducreyi bacteria, cytotoxin, endotoxin and antibodies in animal models for study of chancroid.杜克雷嗜血杆菌、细胞毒素、内毒素及抗体在软下疳研究动物模型中的作用
Microb Pathog. 1992 Sep;13(3):203-17. doi: 10.1016/0882-4010(92)90021-f.
6
Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection.在人类杜克雷嗜血杆菌感染模型中对同基因溶血素缺陷突变体的评估。
J Infect Dis. 1998 Jul;178(1):191-9. doi: 10.1086/515617.
7
Examination of early interactions between Haemophilus ducreyi and host cells by using cocultured HaCaT keratinocytes and foreskin fibroblasts.利用共培养的HaCaT角质形成细胞和包皮成纤维细胞研究杜克雷嗜血杆菌与宿主细胞之间的早期相互作用。
Infect Immun. 1999 Oct;67(10):5352-60. doi: 10.1128/IAI.67.10.5352-5360.1999.
8
Evidence of Haemophilus ducreyi adherence to and cytotoxin destruction of human epithelial cells.杜克雷嗜血杆菌对人上皮细胞的黏附及细胞毒素破坏作用的证据。
Microb Pathog. 1993 Jun;14(6):417-31. doi: 10.1006/mpat.1993.1041.
9
Expression of cytolethal distending toxin and hemolysin is not required for pustule formation by Haemophilus ducreyi in human volunteers.杜克雷嗜血杆菌在人类志愿者中形成脓疱并不需要细胞致死性膨胀毒素和溶血素的表达。
Infect Immun. 2001 Mar;69(3):1938-42. doi: 10.1128/IAI.69.3.1938-1942.2001.
10
Characterization of the cytopathic effect of Haemophilus ducreyi.杜克雷嗜血杆菌细胞病变效应的特征描述。
Sex Transm Dis. 1994 Sep-Oct;21(5):247-57. doi: 10.1097/00007435-199409000-00002.

引用本文的文献

1
Molecular characterization of the interaction of sialic acid with the periplasmic binding protein from .唾液酸与. 周质结合蛋白相互作用的分子特征
J Biol Chem. 2018 Dec 28;293(52):20073-20084. doi: 10.1074/jbc.RA118.005151. Epub 2018 Oct 12.
2
Identification of genes involved in the expression of atypical lipooligosaccharide structures from a second class of Haemophilus ducreyi.从第二类杜克雷嗜血杆菌中鉴定参与非典型脂寡糖结构表达的基因。
Infect Immun. 2007 Jan;75(1):113-21. doi: 10.1128/IAI.01016-06. Epub 2006 Oct 9.
3
Identification of a novel sialic acid transporter in Haemophilus ducreyi.在杜克嗜血杆菌中鉴定出一种新型唾液酸转运蛋白。
Infect Immun. 2005 Oct;73(10):6727-35. doi: 10.1128/IAI.73.10.6727-6735.2005.
4
The LspB protein is involved in the secretion of the LspA1 and LspA2 proteins by Haemophilus ducreyi.LspB蛋白参与了杜克雷嗜血杆菌对LspA1和LspA2蛋白的分泌过程。
Infect Immun. 2004 Apr;72(4):1874-84. doi: 10.1128/IAI.72.4.1874-1884.2004.
5
A CdtA-CdtC complex can block killing of HeLa cells by Haemophilus ducreyi cytolethal distending toxin.CdtA-CdtC复合物可阻断杜克雷嗜血杆菌细胞致死性膨胀毒素对HeLa细胞的杀伤作用。
Infect Immun. 2003 Nov;71(11):6633-40. doi: 10.1128/IAI.71.11.6633-6640.2003.
6
Inhibition of phagocytosis by Haemophilus ducreyi requires expression of the LspA1 and LspA2 proteins.杜克雷嗜血杆菌对吞噬作用的抑制需要LspA1和LspA2蛋白的表达。
Infect Immun. 2003 Oct;71(10):5994-6003. doi: 10.1128/IAI.71.10.5994-6003.2003.
7
Mutations in the lspA1 and lspA2 genes of Haemophilus ducreyi affect the virulence of this pathogen in an animal model system.杜氏嗜血杆菌lspA1和lspA2基因的突变影响该病原体在动物模型系统中的毒力。
Infect Immun. 2003 May;71(5):2478-86. doi: 10.1128/IAI.71.5.2478-2486.2003.
8
Development of a rapid immunodiagnostic test for Haemophilus ducreyi.一种针对杜克雷嗜血杆菌的快速免疫诊断检测方法的研发。
J Clin Microbiol. 2002 Oct;40(10):3694-702. doi: 10.1128/JCM.40.10.3694-3702.2002.
9
Haemophilus ducreyi requires the flp gene cluster for microcolony formation in vitro.杜克雷嗜血杆菌在体外形成微菌落需要flp基因簇。
Infect Immun. 2002 Jun;70(6):2965-75. doi: 10.1128/IAI.70.6.2965-2975.2002.
10
The lbgAB gene cluster of Haemophilus ducreyi encodes a beta-1,4-galactosyltransferase and an alpha-1,6-DD-heptosyltransferase involved in lipooligosaccharide biosynthesis.杜克雷嗜血杆菌的lbgAB基因簇编码一种参与脂寡糖生物合成的β-1,4-半乳糖基转移酶和一种α-1,6-DD-庚糖基转移酶。
Infect Immun. 2002 Jun;70(6):2853-61. doi: 10.1128/IAI.70.6.2853-2861.2002.

本文引用的文献

1
Cloning and characterization of the genes encoding the hemolysin of Haemophilus ducreyi.杜克雷嗜血杆菌溶血素编码基因的克隆与特性分析
Mol Microbiol. 1995 Dec;18(5):821-30. doi: 10.1111/j.1365-2958.1995.18050821.x.
2
Haemophilus ducreyi adheres to but does not invade cultured human foreskin cells.杜克雷嗜血杆菌粘附于培养的人包皮细胞，但不侵入细胞。
Infect Immun. 1993 May;61(5):1735-42. doi: 10.1128/iai.61.5.1735-1742.1993.
3
Look-back investigation after human immunodeficiency virus seroconversion in a pediatric dentist.
J Infect Dis. 1994 Jan;169(1):1-8. doi: 10.1093/infdis/169.1.1.
4
Experimental human infection with Haemophilus ducreyi.人感染杜克雷嗜血杆菌的实验研究。
J Infect Dis. 1994 May;169(5):1146-50. doi: 10.1093/infdis/169.5.1146.
5
Recent changes in the epidemiology of genital ulcer disease in the United States. The crack cocaine connection.美国生殖器溃疡疾病流行病学的近期变化。快克可卡因的关联。
Sex Transm Dis. 1994 Mar-Apr;21(2 Suppl):S76-80.
6
Identification of a hemolytic activity elaborated by Haemophilus ducreyi.杜克雷嗜血杆菌产生的溶血活性的鉴定。
Infect Immun. 1994 Jul;62(7):3041-3. doi: 10.1128/iai.62.7.3041-3043.1994.
7
Haemophilus ducreyi attaches to and invades human epithelial cells in vitro.杜克嗜血杆菌在体外可黏附并侵入人上皮细胞。
Infect Immun. 1994 Dec;62(12):5632-40. doi: 10.1128/iai.62.12.5632-5640.1994.
8
Use of tissue culture and animal models to identify virulence-associated traits of Haemophilus ducreyi.利用组织培养和动物模型鉴定杜克雷嗜血杆菌的毒力相关特性。
Infect Immun. 1995 May;63(5):1754-61. doi: 10.1128/iai.63.5.1754-1761.1995.
9
Swine model of Haemophilus ducreyi infection.杜克雷嗜血杆菌感染的猪模型。
Infect Immun. 1995 Aug;63(8):3094-100. doi: 10.1128/iai.63.8.3094-3100.1995.
10
Characterization of the hemolytic activity of Haemophilus ducreyi.杜克雷嗜血杆菌溶血活性的鉴定
Infect Immun. 1995 Nov;63(11):4409-16. doi: 10.1128/iai.63.11.4409-4416.1995.

杜克雷嗜血杆菌溶血素作为一种接触性细胞毒素，在细胞培养中会损伤人包皮成纤维细胞。

Haemophilus ducreyi hemolysin acts as a contact cytotoxin and damages human foreskin fibroblasts in cell culture.

作者信息

Alfa M J, DeGagne P, Totten P A

机构信息

Microbiology Department, St Boniface General Hospital, Winnipeg, Manitoba, Canada.

出版信息

Infect Immun. 1996 Jun;64(6):2349-52. doi: 10.1128/iai.64.6.2349-2352.1996.

DOI:10.1128/iai.64.6.2349-2352.1996
PMID:8675349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174078/
Abstract

Haemophilus ducreyi, which causes the sexually transmitted disease chancroid, produces several factors that damage human cells. We used isogenic mutants of H. ducreyi 35000 to demonstrate that the hemolytic activity and the cytotoxic effect of H. ducreyi on human foreskin fibroblasts are due to the same toxin.

摘要

引起性传播疾病软下疳的杜克雷嗜血杆菌会产生多种损害人体细胞的因子。我们利用杜克雷嗜血杆菌35000的同基因突变体来证明，杜克雷嗜血杆菌对人包皮成纤维细胞的溶血活性和细胞毒性作用是由同一种毒素所致。