Silberstein S D, Wilmore L J
Temple University School of Medicine, Philadelphia, Penn, USA.
Headache. 1996 Apr;36(4):239-42. doi: 10.1046/j.1526-4610.1996.3604239.x.
Divalproex sodium is an effective drug for the treatment of migraine. Most adverse drug events are transient and not of great clinical concern. Although rare, well-documented examples of liver toxicity have been reported in children under 2 years of age on polypharmacy. Additional cases occur in children under 10 who are receiving polypharmacy, particularly those who have intractable seizures and degenerative central nervous system disease. Clinicians who treat migraineurs with divalproex sodium do not need to be overly preoccupied with monitoring of drug levels and liver function tests. The most valuable test is clinical observation of the patient.
丙戊酸钠是一种治疗偏头痛的有效药物。大多数药物不良事件是短暂的，临床上并不十分令人担忧。虽然罕见，但已有文献充分记载2岁以下接受多种药物治疗的儿童出现肝毒性的例子。其他病例发生在接受多种药物治疗的10岁以下儿童中，尤其是那些患有难治性癫痫和退行性中枢神经系统疾病的儿童。用丙戊酸钠治疗偏头痛患者的临床医生无需过度关注药物水平监测和肝功能检查。最有价值的检查是对患者的临床观察。
