Rothrock J F, Kelly N M, Brody M L, Golbeck A
University of California, San Diego Headache Center.
Cephalalgia. 1994 Jun;14(3):241-4. doi: 10.1046/j.1468-2982.1994.014003241.x.
We consecutively recruited 75 patients with intractable headache syndromes, divided them into three groups (frequent migraine = FM, transformed migraine = TM, and tension type headache = TT) based on their headache symptoms and treated all 75 with divalproex sodium. Thirty-six patients (48%) reported a > or = 50% reduction in headache frequency. We noted significantly different treatment response rates in the three patient groups, with FM patients reporting the highest rate of improvement (11/18 = 61%), TM patients an intermediate rate (22/43 = 51%), and TT patients the lowest response rate (3/14 = 21%). These data suggest that prophylactic therapy with divalproex may be effective in selected patients with intractable headache syndromes and that identification of clinically distinct headache subtypes may assist in predicting response to treatment.
我们连续招募了75例顽固性头痛综合征患者，根据他们的头痛症状将其分为三组（频发偏头痛=FM、转化型偏头痛=TM和紧张型头痛=TT），并使用丙戊酸二钠对这75例患者进行治疗。36例患者（48%）报告头痛频率降低了≥50%。我们注意到三组患者的治疗有效率有显著差异，FM患者的改善率最高（11/18 = 61%），TM患者为中等改善率（22/43 = 51%），TT患者的有效率最低（3/14 = 21%）。这些数据表明，丙戊酸二钠预防性治疗可能对某些顽固性头痛综合征患者有效，并且识别临床上不同的头痛亚型可能有助于预测治疗反应。
