Clerehugh V, Drucker D B, Seymour G J, Bird P S
University Dental Hospital of Manchester.
J Clin Pathol. 1996 Mar;49(3):255-7. doi: 10.1136/jcp.49.3.255.
Microbiological and serological (enzyme linked immunosorbent assay) investigations were carried out, including karyotyping, on two Asian children with Papillon-Lefèvre syndrome. In case 1, a girl aged four years, the most prevalent putative periodontopathogens were Eikenella corrodens, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia (deciduous dentition) and Bacteroides gracilis, E corrodens and F nucleatum (permanent dentition). In case 2, a boy aged nine years, they were F nucleatum, P intermedia and P loeschii and E corrodens. Serum from case 2 showed a raised specific IgG antibody response to Actinomyces actino-mycetemcomitans serotype b. Thus, a wider range of species than hitherto reported may be associated with Papillon-Lefèvre syndrome, including A actino-mycetemcomitans and F nucleatum.
对两名患有帕皮永-勒费夫尔综合征的亚洲儿童进行了微生物学和血清学（酶联免疫吸附测定）研究，包括核型分析。病例1是一名4岁女孩，最常见的假定牙周病原体是腐蚀埃肯菌、具核梭杆菌、牙龈卟啉单胞菌、中间普雷沃菌（乳牙列）以及纤细拟杆菌、腐蚀埃肯菌和具核梭杆菌（恒牙列）。病例2是一名9岁男孩，病原体是具核梭杆菌、中间普雷沃菌和洛氏普雷沃菌以及腐蚀埃肯菌。病例2的血清显示对伴放线放线杆菌b血清型的特异性IgG抗体反应升高。因此，与帕皮永-勒费夫尔综合征相关的物种范围可能比迄今报道的更广，包括伴放线放线杆菌和具核梭杆菌。
