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两种B细胞特异性转录共激活因子之间的结合与协同相互作用。

Binding and cooperative interactions between two B cell-specific transcriptional coactivators.

作者信息

Fontes J D, Jabrane-Ferrat N, Toth C R, Peterlin B M

机构信息

Howard Hughes Medical Institute, Departments of Medicine, University of California, at San Francisco 94143-0724, USA.

出版信息

J Exp Med. 1996 Jun 1;183(6):2517-21. doi: 10.1084/jem.183.6.2517.

DOI:10.1084/jem.183.6.2517
PMID:8676072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2192624/
Abstract

The class II transactivator (CIITA) and B cell octamer-binding protein 1/octamer-binding factor 1/Oct coactivator from B cells (Bob1/OBF-1/OCA-B) represent two B cell-specific transcriptional coactivators. CIITA and Bob1 interact with proteins that bind to conserved upstream sequences in promoters of class II major histocompatibility genes and octamer-binding transcription factors Oct-1 and Oct-2, respectively. Both CIITA and Bob1 increase the expression from the DRA promoter, which is a prototypic class II promoter. Moreover, in the presence of CIITA, interactions between class II promoters and Bob1 are independent of the octamer-binding site. Using in vivo and in vitro binding assays, we confirm that Bob1 binds to CIITA. Thus, CIITA not only activates the expression of class II genes but recruits another B cell-specific coactivator to increase transcriptional activity of class II promoters in B cells.

摘要

II类反式激活因子（CIITA）和B细胞八聚体结合蛋白1/八聚体结合因子1/B细胞Oct共激活因子（Bob1/OBF-1/OCA-B）代表两种B细胞特异性转录共激活因子。CIITA和Bob1分别与结合在II类主要组织相容性基因启动子中保守上游序列的蛋白质以及八聚体结合转录因子Oct-1和Oct-2相互作用。CIITA和Bob1均可增加DRA启动子的表达，DRA启动子是II类启动子的原型。此外，在有CIITA存在的情况下，II类启动子与Bob1之间的相互作用独立于八聚体结合位点。通过体内和体外结合试验，我们证实Bob1与CIITA结合。因此，CIITA不仅激活II类基因的表达，还招募另一种B细胞特异性共激活因子以增加B细胞中II类启动子的转录活性。

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