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HIV-2 and SIV infection of nonprimate cell lines expressing human CD4: restrictions to replication at distinct stages.
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High proportion of HIV-2 and HIV-1/2 double-reactive sera in two Indian states, Maharashtra and Goa: first appearance of an HIV-2 epidemic along with an HIV-1 epidemic outside of Africa.
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Specificity of antipeptide antibodies produced against V2 and V3 regions of the external envelope of human immunodeficiency virus type 2.针对2型人类免疫缺陷病毒外膜V2和V3区域产生的抗肽抗体的特异性
Mol Immunol. 1994 Apr;31(5):361-9. doi: 10.1016/0161-5890(94)90114-7.
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Genetic analysis of human immunodeficiency virus type 1 and 2 (HIV-1 and HIV-2) mixed infections in India reveals a recent spread of HIV-1 and HIV-2 from a single ancestor for each of these viruses.对印度人类免疫缺陷病毒1型和2型（HIV - 1和HIV - 2）混合感染的基因分析表明，HIV - 1和HIV - 2这两种病毒均源自单一祖先且近期出现了传播。
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Two neutralizing domains in the V3 region in the envelope glycoprotein gp125 of HIV type 2.2型人类免疫缺陷病毒包膜糖蛋白gp125的V3区域中的两个中和结构域。
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Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization.包膜V3区表位的隐蔽性保护嗜单核细胞性1型人类免疫缺陷病毒免受抗体中和。
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Detection of human immunodeficiency virus antibody among homosexual men from Bombay.孟买同性恋男性人群中人类免疫缺陷病毒抗体的检测
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Characterization of monoclonal antibodies to human immunodeficiency virus type 2 envelope glycoproteins.针对人类免疫缺陷病毒2型包膜糖蛋白的单克隆抗体的特性分析
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Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates.来自原发性和经T细胞系传代的1型人类免疫缺陷病毒分离株的包膜糖蛋白的复制功能和中和敏感性
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2型人类免疫缺陷病毒表面糖蛋白（SU）上中和及非中和表位的定位、暴露与保守性

Location, exposure, and conservation of neutralizing and nonneutralizing epitopes on human immunodeficiency virus type 2 SU glycoprotein.

作者信息

McKnight A, Shotton C, Cordell J, Jones I, Simmons G, Clapham P R

机构信息

Virology Laboratory, Chester Beatty Laboratories, The Institute of Cancer Research, London, United Kingdom.

出版信息

J Virol. 1996 Jul;70(7):4598-606. doi: 10.1128/JVI.70.7.4598-4606.1996.

DOI:10.1128/JVI.70.7.4598-4606.1996
PMID:8676486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190396/
Abstract

Eleven rat monoclonal antibodies (MAbs) that recognize the SU glycoprotein of human immunodeficiency virus type 2 (HIV-2) ROD were produced and characterized. Binding sites for eight of these MAbs were mapped to epitopes within the Cl, V1/V2, C2, and V3 envelope regions. The three other MAbs defined at least two conformation-dependent, strain-specific epitopes outside Vl/V2, V3, and the CD4-binding site. The MAbs were used to probe the tertiary structure of oligomeric envelope glycoprotein expressed on the surfaces of infected cells. Epitopes at the apices of V2 and V3 were exposed on the native molecule, whereas other epitopes on V1/V2, Cl, and C2 were hidden. The MAbs defined three neutralization targets on exposed domains: two linear epitopes in the V2 and the V3 loops and one conformational epitope outside V1, V2, and V3.

摘要

制备并鉴定了11种识别2型人类免疫缺陷病毒（HIV-2）ROD株SU糖蛋白的大鼠单克隆抗体（MAb）。其中8种MAb的结合位点被定位到Cl、V1/V2、C2和V3包膜区域内的表位。另外3种MAb确定了至少两个位于V1/V2、V3和CD4结合位点之外的构象依赖性、毒株特异性表位。这些MAb被用于探测感染细胞表面表达的寡聚包膜糖蛋白的三级结构。V2和V3顶端的表位暴露于天然分子上，而V1/V2、Cl和C2上的其他表位则被隐藏。这些MAb确定了暴露结构域上的三个中和靶点：V2和V3环中的两个线性表位以及V1、V2和V3之外的一个构象表位。