亚单位疫苗接种后人类CD4 + T细胞对甲型流感病毒血凝素的识别
Human CD4+ T-cell recognition of influenza A virus hemagglutinin after subunit vaccination.
作者信息
Gelder C M, Lamb J R, Askonas B A
机构信息
Infection and Immunity Section, Department of Biology, Imperial College of Science, Technology and Medicine, London, United Kingdom.
出版信息
J Virol. 1996 Jul;70(7):4787-90. doi: 10.1128/JVI.70.7.4787-4790.1996.
Abstract
We have examined human CD4+ T-cell recognition of influenza A/Beijing/32/92 (H3N2) virus hemagglutinin following influenza virus HANA subunit vaccination. CD4+ T-cell repertoires were dominated by recognition of epitopes located in conserved regions of the molecule, in a major histocompatibility complex class II haplotype-dependent manner, analogous to that observed following natural infection.
摘要
我们检测了甲型流感病毒/北京/32/92（H3N2）血凝素在流感病毒血凝素神经氨酸酶亚单位疫苗接种后人类CD4 + T细胞的识别情况。CD4 + T细胞库主要由位于分子保守区域的表位识别所主导，呈主要组织相容性复合体II类单倍型依赖性方式，类似于自然感染后观察到的情况。
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本文引用的文献
1
Cytotoxic T lymphocytes specific for influenza virus.对流感病毒具有特异性的细胞毒性T淋巴细胞。
Curr Top Microbiol Immunol. 1994;189:75-91. doi: 10.1007/978-3-642-78530-6_5.
2
Human CD4+ T-cell repertoire of responses to influenza A virus hemagglutinin after recent natural infection.近期自然感染后人类对甲型流感病毒血凝素反应的CD4+ T细胞库。
J Virol. 1995 Dec;69(12):7497-506. doi: 10.1128/JVI.69.12.7497-7506.1995.
3
4
Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites.1968年至1980年流感病毒H3血凝素的抗原漂移：关键抗原位点的多种进化途径和连续氨基酸变化
J Virol. 1983 Oct;48(1):52-60. doi: 10.1128/JVI.48.1.52-60.1983.
5
Molecular mechanisms of variation in influenza viruses.流感病毒变异的分子机制
Nature. 1982 Mar 11;296(5853):115-21. doi: 10.1038/296115a0.
6
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation.香港流感血凝素抗体结合位点的结构鉴定及其在抗原变异中的作用。
Nature. 1981 Jan 29;289(5796):373-8. doi: 10.1038/289373a0.
7
Antibody responses to antigenic determinants of influenza virus hemagglutinin. I. Thymus dependence of antibody formation and thymus independence of immunological memory.针对流感病毒血凝素抗原决定簇的抗体反应。I. 抗体形成的胸腺依赖性及免疫记忆的胸腺非依赖性
J Exp Med. 1974 Dec 1;140(6):1559-70. doi: 10.1084/jem.140.6.1559.
8
T-cell differentiation and effector functions.
Immunol Suppl. 1988;1:51-2.
9
The role of IL-2 and T4+ cells in the generation of human influenza virus-specific CTL activity.白细胞介素-2和T4 +细胞在人流感病毒特异性细胞毒性T淋巴细胞活性产生中的作用。
Cell Immunol. 1986 Jul;100(2):462-73. doi: 10.1016/0008-8749(86)90045-6.
10
Do L3T4+ T cells act as effector cells in protection against influenza virus infection.L3T4+ T细胞在抵抗流感病毒感染的过程中是否作为效应细胞发挥作用？
Immunology. 1987 Sep;62(1):139-44.
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