香港流感血凝素抗体结合位点的结构鉴定及其在抗原变异中的作用。
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation.
作者信息
Wiley D C, Wilson I A, Skehel J J
出版信息
Nature. 1981 Jan 29;289(5796):373-8. doi: 10.1038/289373a0.
DOI:10.1038/289373a0
PMID:6162101
Abstract
Four 'antigenic sites' on the three-dimensional structure of the influenza haemagglutinin are identified. At least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.
摘要
流感血凝素三维结构上的四个“抗原位点”已被确定。在1968年至1975年间产生新的流行毒株似乎每个位点至少需要一个氨基酸替换。
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