Kawai T, Itoh Y, Hirabayashi Y, Ichihara K, Igarashi S, Iwata S, Kawano K, Kanno T, Ohkubo A, Saitoh K, Sugahara T
Department of Clinical Pathology, Jichi Medical School, Tochigi, Japan.
Rinsho Byori. 1996 May;44(5):429-34.
Using a nephelometry with a new calibrator in which values were assigned from EU/CRM470, a new international reference preparation, we have established for the first time the reference intervals of 13 different serum proteins in Japanese adults. Based on the NCCLS guideline C28-P, a new statistical and concrete procedure was revised and used for this study. It is clearly shown here that standardisation of serum proteins can be possible under the qualified assay system, making it possible to share the reference intervals among laboratories under well-controlled quality assurance. New aspects of serum protein variations were discovered in relation to physiologic changes and life styles.
我们使用一种配备新型校准物的散射比浊法，该校准物的值源自一种新的国际参考制剂——欧盟/CRM470，首次确立了日本成年人13种不同血清蛋白的参考区间。基于美国国家临床实验室标准委员会（NCCLS）的C28-P指南，我们修订并采用了一种新的统计和具体程序用于本研究。结果清楚表明，在合格的检测系统下血清蛋白的标准化是可行的，这使得在严格控制质量保证的情况下各实验室能够共享参考区间。研究还发现了血清蛋白变化与生理变化及生活方式相关的新情况。
