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[多发性硬化症中的发作性睡病]

[Hypersomnia in multiple sclerosis].

作者信息

Schlüter B, Aguigah G, Andler W

机构信息

Vestische Kinderklinik Datteln, Universität Witten-Herdecke.

出版信息

Klin Padiatr. 1996 May-Jun;208(3):103-5. doi: 10.1055/s-2008-1046455.

Abstract

A 13-year-old girl presented with hyersomnia and incontinence of urine. The clinical course was complicated by strabism, muscle weakness and coordination and balance disturbances. VEP recording were pathologic. Myelin basic protein in the cerebrospinal fluid was elevated. Nuclear resonance imaging of the brain revealed multiple areas of demyelination. These findings supported the diagnosis of multiple sclerosis. There was a marked disturbance of the sleep-waking-pattern during the acute phase of the illness. The hypnogram resembled the pattern of polysymptomatic narcolepsy. Regression of symptoms was noted with dexamethasone therapy.

摘要

一名13岁女孩出现嗜睡和尿失禁。临床过程因斜视、肌肉无力以及协调和平衡障碍而变得复杂。视觉诱发电位记录显示病理改变。脑脊液中的髓鞘碱性蛋白升高。脑部核磁共振成像显示多个脱髓鞘区域。这些发现支持多发性硬化的诊断。在疾病急性期,睡眠-觉醒模式有明显紊乱。睡眠图类似于多症状发作性睡病的模式。地塞米松治疗后症状有所缓解。

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