超声子宫内膜厚度与孕激素引起的撤退性出血之间的关系。

Relationship between sonographic endometrial thickness and progestin-induced withdrawal bleeding.

作者信息

Nakamura S, Douchi T, Oki T, Ijuin H, Yamamoto S, Nagata Y

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Japan.

出版信息

Obstet Gynecol. 1996 May;87(5 Pt 1):722-5. doi: 10.1016/0029-7844(96)00016-6.

DOI:10.1016/0029-7844(96)00016-6

PMID:8677074

Abstract

OBJECTIVE

To determine whether the response to the progestin challenge test can be predicted from the endometrial thickness measured sonographically.

METHODS

Progestin challenge tests were performed on 44 women with secondary amenorrhea, each of whom also had her endometrial thickness measured by transvaginal ultrasonography and her serum estradiol (E2) levels determined. The relationships between the response to the challenge test, endometrial thickness, and serum E2 levels were studied, as well as whether the presence or absence of withdrawal bleeding could be predicted from the endometrial thickness and serum E2 levels.

RESULTS

The endometrium was significantly thicker in 32 women who had withdrawal bleeding (10.3 +/-4.1 mm) than in the 12 who did not bleed (5.0 +/- 1.3 mm) (P < .001). The serum E2 level was also significantly higher in the positive group: 45.3 +/- 19.4 versus 18.6 +/- 8.0 pg/mL (P < .001). Endometrial thickness of 6.0 mm or more predicted the occurrence of withdrawal bleeding with an accuracy of 95.5%. Endometrial thickness was superior to the serum E2 level in predicting withdrawal bleeding.

CONCLUSION

Progestin-induced withdrawal bleeding can be predicted from the endometrial thickness measured sonographically.

摘要

目的

确定能否通过超声测量的子宫内膜厚度来预测孕激素激发试验的反应。

方法

对44例继发性闭经女性进行孕激素激发试验，每位女性均经阴道超声测量子宫内膜厚度并测定血清雌二醇（E2）水平。研究激发试验反应、子宫内膜厚度和血清E2水平之间的关系，以及能否根据子宫内膜厚度和血清E2水平预测是否出现撤退性出血。

结果

32例出现撤退性出血的女性子宫内膜明显更厚（10.3±4.1mm），高于12例未出血女性（5.0±1.3mm）（P<.001）。阳性组血清E2水平也显著更高：45.3±19.4与18.6±8.0pg/mL（P<.001）。子宫内膜厚度6.0mm及以上预测撤退性出血发生的准确率为95.5%。在预测撤退性出血方面，子宫内膜厚度优于血清E2水平。