Morcos R N, Leonard M D, Smith M, Bourguet C, Makii M, Khawli O
Department of Obstetrics and Gynecology, St. Elizabeth Hospital Medical Center, Youngstown, Ohio 44501.
Fertil Steril. 1991 Mar;55(3):543-6. doi: 10.1016/s0015-0282(16)54182-x.
The progestin-induced withdrawal bleeding test has often been used in patients with amenorrhea to assess endogenous estrogen (E) production. The endometrial thickness measured by vaginal ultrasonography with a 5 MHz transducer is also dependent on E stimulation of the endometrium. In this study, 70 consecutive patients were evaluated with both the progestin-induced withdrawal bleeding test and a measurement of the endometrial thickness by vaginosonography. An endometrial thickness of 1.5 mm or less was selected to predict absence of bleeding after a progesterone (P) challenge test. This resulted in a sensitivity of 94% with a 95% confidence interval (CI) of 0.70 to 1.00 and a specificity of 93% with a 95% CI of 0.82 and 0.98. The positive and negative predictive values were 79% and 98%, respectively. This study shows that the endometrial thickness measured by vaginosonography can predict the results of the P challenge test in patients with amenorrhea.
孕激素撤退性出血试验常用于闭经患者，以评估内源性雌激素（E）的产生。使用5MHz探头经阴道超声测量的子宫内膜厚度也取决于子宫内膜的雌激素刺激。在本研究中，对70例连续患者进行了孕激素撤退性出血试验及经阴道超声测量子宫内膜厚度的评估。选择子宫内膜厚度为1.5mm或更小来预测孕酮（P）激发试验后无出血。这导致敏感性为94%，95%置信区间（CI）为0.70至1.00，特异性为93%，95%CI为0.82至0.98。阳性和阴性预测值分别为79%和98%。本研究表明，经阴道超声测量的子宫内膜厚度可预测闭经患者P激发试验的结果。
