Dale P D, Sherratt J A, Maini P K
Centre for Mathematical Biology, Mathematical Institute, Oxford, U.K.
Proc Biol Sci. 1996 May 22;263(1370):653-60. doi: 10.1098/rspb.1996.0098.
Adult dermal wounds, in contrast to foetal wounds, heal with the formation of scar tissue. A crucial factor in determining the nature of the healed tissue is the ratio of collagen 1 to collagen 3, which regulates the diameter of collagen fibres. We develop a mathematical model which focuses on the stimulus for collagen synthesis due to the secretion of the different isoforms of the regulatory chemical transforming growth factor beta. Numerical simulations of the model lead to a value of this ratio consistent with that of healthy tissue for the foetus but corresponding to scarring in adult wound healing. We investigate the effect of topical application of TGF beta isoforms during healing and determine the key parameters which control the difference between adult and foetal repair.
与胎儿伤口不同，成人皮肤伤口愈合时会形成瘢痕组织。决定愈合组织性质的一个关键因素是1型胶原蛋白与3型胶原蛋白的比例，该比例调节着胶原纤维的直径。我们开发了一个数学模型，该模型聚焦于由调节性化学物质转化生长因子β的不同亚型分泌所引起的胶原蛋白合成刺激。该模型的数值模拟得出的这个比例值，与胎儿健康组织的比例值一致，但与成人伤口愈合中的瘢痕形成相对应。我们研究了愈合过程中局部应用转化生长因子β亚型的效果，并确定了控制成人和胎儿修复差异的关键参数。
