Kirschner C V, Alanis-Amezcua J M, Martin V G, Luna N, Morgan E, Yang J J, Yordan E L
Department of Obstetrics and Gynecology, Lutheran General Hospital, Park Ridge, Illinois, USA.
Am J Obstet Gynecol. 1996 Jun;174(6):1879-82; discussion 1882-4. doi: 10.1016/s0002-9378(96)70224-7.
Tumor angiogenesis is believed to be a prognostic indicator associated with tumor growth and metastasis. Studies of angiogenesis in breast, prostate, and lung cancer, as well as melanoma, have shown that neovascularization correlates with the likelihood of metastasis and recurrences. The purpose of this study was to evaluate microvessel density as a prognostic factor in endometrial cancer.
Between 1980 and 1991 the tumor registry identified 25 patients with a diagnosis of recurrent endometrial cancer. These patients were matched with 25 patients with nonrecurrent disease for age, stage, grade, and treatment. The histologic slides of the 50 patients were reviewed. The paraffin blocks were obtained, and the area of the deepest myometrial invasion was selected for staining. The microvessels within the invasive cancer were highlighted by means of immunocytochemical staining to detect factor VIII-related antigen. Microvessels were counted by two investigators who were blinded to the patients' clinical status. Survival data were analyzed with Kaplan-Meier survival curves.
Microvessel count was related to likelihood of recurrence, although this trend did not reach statistical significance. Patients with tumors of low capillary density had a mean survival time of 123 months. Patients with tumors of high capillary density had a mean survival time of 75 months (p = 0.02). Among patients with recurrent disease, those with a low capillary count survived a mean of 64 months. Patients with recurrent disease with tumors of high capillary density survived a mean of 45 months (p = 0.002).
Angiogenesis factor correlates with survival in endometrial carcinoma.
肿瘤血管生成被认为是与肿瘤生长和转移相关的预后指标。对乳腺癌、前列腺癌、肺癌以及黑色素瘤的血管生成研究表明，新血管形成与转移和复发的可能性相关。本研究的目的是评估微血管密度作为子宫内膜癌的预后因素。
1980年至1991年间，肿瘤登记处确定了25例复发性子宫内膜癌患者。这些患者与25例非复发性疾病患者在年龄、分期、分级和治疗方面进行了匹配。对这50例患者的组织学切片进行了复查。获取石蜡块，选择最深肌层浸润区域进行染色。通过免疫细胞化学染色突出侵袭性癌内的微血管，以检测因子VIII相关抗原。由两名对患者临床状况不知情的研究人员对微血管进行计数。生存数据采用Kaplan-Meier生存曲线进行分析。
微血管计数与复发可能性相关，尽管这一趋势未达到统计学意义。毛细血管密度低的肿瘤患者平均生存时间为123个月。毛细血管密度高的肿瘤患者平均生存时间为75个月（p = 0.02）。在复发性疾病患者中，毛细血管计数低的患者平均存活64个月。复发性疾病且肿瘤毛细血管密度高的患者平均存活45个月（p = 0.002）。
血管生成因子与子宫内膜癌的生存相关。
