Salvesen H B, Iversen O E, Akslen L A
Department of Gynaecology and Obstetrics, The Gade Institute, Haukeland University Hospital, Bergen, Norway.
Br J Cancer. 1998 Apr;77(7):1140-4. doi: 10.1038/bjc.1998.189.
Angiogenesis is thought to be an important factor for tumour growth and metastatic spread, and microvessel counts may provide useful prognostic information for several tumour types. To investigate the prognostic impact of angiogenesis in endometrial carcinoma patients, the intratumour microvessel density, which was determined immunohistochemically, has been related to survival. Sixty patients with endometrial carcinoma with long (median 19 years) and complete follow-up have been studied. Patients with increased mean microvessel density (MVDmean > 68 mm2) had a significantly shorter 5-year survival compared with the rest (57% vs 90%, P = 0.004). In multivariate survival analyses, MVDmean had an independent prognostic impact (P = 0.03) when FIGO stage, histological type, histological grade as well as nuclear p53 protein expression was adjusted for. These findings indicate that intratumour microvessel density may contribute additional prognostic information to that obtained from the known risk factors and may be helpful in identifying endometrial carcinoma patients at high risk for disease progression.
血管生成被认为是肿瘤生长和转移扩散的一个重要因素，微血管计数可能为几种肿瘤类型提供有用的预后信息。为了研究血管生成对子宫内膜癌患者的预后影响，通过免疫组织化学测定的肿瘤内微血管密度与生存率相关。对60例子宫内膜癌患者进行了长期（中位时间19年）且完整的随访研究。平均微血管密度增加（MVDmean > 68 mm2）的患者与其余患者相比，5年生存率显著缩短（57% 对 90%，P = 0.004）。在多因素生存分析中，在对国际妇产科联盟（FIGO）分期、组织学类型、组织学分级以及核p53蛋白表达进行校正后，MVDmean具有独立的预后影响（P = 0.03）。这些发现表明，肿瘤内微血管密度可能为从已知风险因素中获得的信息提供额外的预后信息，并且可能有助于识别疾病进展风险高的子宫内膜癌患者。
