Handa K, Takao M, Nomoto J, Oku K, Shirai K, Saku K, Arakawa K
Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
Angiology. 1996 Jun;47(6):543-8. doi: 10.1177/000331979604700602.
The authors evaluated elements of the coagulation and fibrinolytic systems in 18 male patients with intermittent claudication vs 19 men matched for risk factors who served as controls. Prothrombin time and activated partial thromboplastin time did not significantly differ in the patients and the controls. The plasminogen level in the two groups was not significantly different. The level of lipoprotein(a) was significantly higher in the patients than in the controls. The levels of antigen and the activity of protein C did not differ significantly between the two groups. The thrombomodulin level was significantly higher in the patients than in the controls. There were no significant differences between the two groups in the levels of alpha 2-macroglobulin, C1-inactivator, or antithrombin III. The levels of fibrinogen and alpha 1-antitrypsin were significantly higher in the patients vs the controls. Significantly lower levels of alpha 2-plasmin inhibitor and higher levels of alpha 2-plasmin inhibitor/plasmin complex and thrombin/antithrombin III complex were found in the patients vs the controls. These findings suggest that the levels of thrombin/antithrombin III complex, alpha 2-plasmin inhibitor/plasmin complex, and thrombomodulin may perhaps serve as indicators for injury to the peripheral endothelium and that the coagulation and fibrinolytic systems may be activated in patients with intermittent claudication.
作者评估了18例间歇性跛行男性患者与19例匹配了危险因素的男性对照者的凝血和纤溶系统指标。患者与对照者的凝血酶原时间和活化部分凝血活酶时间无显著差异。两组的纤溶酶原水平无显著差异。患者的脂蛋白(a)水平显著高于对照者。两组之间蛋白C的抗原水平和活性无显著差异。患者的血栓调节蛋白水平显著高于对照者。两组在α2-巨球蛋白、C1-灭活剂或抗凝血酶III水平上无显著差异。患者的纤维蛋白原和α1-抗胰蛋白酶水平显著高于对照者。与对照者相比，患者的α2-纤溶酶抑制剂水平显著降低，α2-纤溶酶抑制剂/纤溶酶复合物和凝血酶/抗凝血酶III复合物水平升高。这些发现表明，凝血酶/抗凝血酶III复合物、α2-纤溶酶抑制剂/纤溶酶复合物和血栓调节蛋白水平可能可作为外周内皮损伤的指标，且间歇性跛行患者的凝血和纤溶系统可能被激活。
