Hetherington H E, Hollinger J O, Morris M R, Panje W R
Otolaryngology Service, Madigan Army Medical Center, Tacoma, Washington, USA.
Ann Otol Rhinol Laryngol. 1996 Jul;105(7):568-73. doi: 10.1177/000348949610500714.
The repair of contour defects of craniofacial bone can be accomplished by several methods, including autogenous bone grafts, demineralized bone, and alloplastic materials. The objective of this study was to assess a biodegradable, xenogeneic, osteoinductive implant for craniofacial onlay bone augmentation. Twelve New Zealand White rabbits each had craniofacial onlays consisting of three experimental materials: 1) autograft; 2) allogeneic, demineralized block implant; and 3) partially purified osteoinductive protein (osteogenin) with allogeneic collagen and 50:50 poly (DL-lactide-co-glycolide). Implants with host bone were recovered after 20 weeks and assessed by histomorphometric methods. There was no evidence of adverse local reaction to the three treatments. No significant difference in bone replacement or bone density resulting from each of the implant types was demonstrated. In conclusion, the osteoinductive implants were well tolerated, and over the 20-week period they appeared to maintain their contour as onlays.
颅面骨轮廓缺损的修复可通过多种方法实现，包括自体骨移植、脱矿骨和异体材料。本研究的目的是评估一种用于颅面贴骨增高术的可生物降解的异种骨诱导植入物。12只新西兰白兔均进行了颅面贴骨手术，所用材料有三种：1）自体移植骨；2）同种异体脱矿块状植入物；3）部分纯化的骨诱导蛋白（骨生成素）与同种异体胶原蛋白及50:50的聚（DL-丙交酯-共-乙交酯）。20周后取出植入物与宿主骨，采用组织形态计量学方法进行评估。未发现三种治疗方法有局部不良反应的证据。未显示出每种植入物类型在骨替代或骨密度方面有显著差异。总之，骨诱导植入物耐受性良好，在20周的时间里，它们作为贴骨植入物似乎保持了其轮廓。
