Tamimi Faleh, Torres Jesus, Gbureck Uwe, Lopez-Cabarcos Enrique, Bassett David C, Alkhraisat Mohammad H, Barralet Jake E
Faculty of Dentistry, McGill University, 3640 University Street, Montreal, H3A 2B2 QC, Canada.
Biomaterials. 2009 Oct;30(31):6318-26. doi: 10.1016/j.biomaterials.2009.07.049. Epub 2009 Aug 19.
Onlay autografting is amongst the most predictable techniques for craniofacial vertical bone augmentation, however, complications related to donor site surgery are common and synthetic alternatives to onlay autografts are desirable. Recent studies have shown that the acidic calcium phosphates, brushite and monetite, are osteoconductive, osteoinductive and resorb faster in vivo than hydroxyapatite. Moreover, they can be 3D printed allowing precise host bone-implant conformation. The objectives of this study were to confirm that craniofacial screw fixation of 3D printed monetite blocks was possible and to compare the resulting vertical bone augmentation with autograft. 3D printed monolithic monetite onlay implants were fixed with osteosynthesis screws on the calvarial bone surface of New Zealand rabbits. After 8 weeks, integration between the implant and the calvarial bone surface was observed in all cases. Histomorphometry revealed that 42% of the monetite was resorbed and that the new bone formed within the implant occupied 43% of its volume, sufficient for immediate dental implant placement. Bone tissue within the autologous onlay occupied 60% of the volume. We observed that patterns of regeneration within the implants differed throughout the material and propose that this was due to the anatomy and blood supply pattern in the region. Rapid prototyped monetite being resorbable osteoconductive and osteoinductive would appear to be a promising biomaterial for many bone regeneration strategies.
外置自体骨移植是颅面垂直骨增量最可预测的技术之一，然而，与供区手术相关的并发症很常见，因此需要合成材料替代外置自体骨移植。最近的研究表明，酸性磷酸钙、透钙磷石和一水磷酸氢钙具有骨传导性、骨诱导性，并且在体内比羟基磷灰石吸收更快。此外，它们可以进行3D打印，从而实现精确的宿主骨与植入物贴合。本研究的目的是确认3D打印的一水磷酸氢钙块进行颅面螺钉固定是可行的，并将由此产生的垂直骨增量与自体骨移植进行比较。将3D打印的整体式一水磷酸氢钙外置植入物用接骨螺钉固定在新西兰兔的颅骨表面。8周后，在所有病例中均观察到植入物与颅骨表面之间的整合。组织形态计量学显示，42%的一水磷酸氢钙被吸收，植入物内形成的新骨占其体积的43%，足以立即植入牙种植体。自体外置骨内的骨组织占体积的60%。我们观察到植入物内的再生模式在整个材料中有所不同，并认为这是由于该区域的解剖结构和血液供应模式所致。快速成型的一水磷酸氢钙具有可吸收性、骨传导性和骨诱导性，似乎是许多骨再生策略中一种很有前景的生物材料。
