Ivanova V, Hristov J, Dobreva E, al-Hassan Z, Penchev I
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Appl Biochem Biotechnol. 1996 May;59(2):187-98. doi: 10.1007/BF02787820.
This paper is focused on the possibility to apply the magnetic stabilization technique in bioprocessing. The feasibility of a continuous ethanol fermentation process with immobilized Saccharomyces cerevisiae cells in a magnetically stabilized bed (MSB) was demonstrated. The fermentation processes were carried out in an external magnetic field, transverse to the fluid flow. The flexibility to change the bed expansion owing to the independent change of the fluid flow and the field intensity (the "magnetization FIRST" mode) permitted the creation of fixed beds with different particle arrangements, which affected the bed porosity, the effective fluid-particle contact area, and the mass transfer processes on the particle-fluid interface. As a result, higher ethanol concentration, ethanol production, and glucose uptake rates than in conventional packed bed reactor were reached.
本文聚焦于将磁稳定技术应用于生物加工的可能性。已证明在磁稳定床（MSB）中利用固定化酿酒酵母细胞进行连续乙醇发酵过程的可行性。发酵过程在与流体流动方向垂直的外部磁场中进行。由于流体流量和场强的独立变化而改变床层膨胀的灵活性（“磁化优先”模式）允许创建具有不同颗粒排列的固定床，这会影响床层孔隙率、有效流体 - 颗粒接触面积以及颗粒 - 流体界面上的传质过程。结果，与传统填充床反应器相比，实现了更高的乙醇浓度、乙醇产量和葡萄糖摄取率。
