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[舒张功能障碍作为高血压患者心力衰竭的一个病因]

[Diastolic dysfunction as a cause of heart failure in the hypertensive patient].

作者信息

Iriarte Ezkurdia M M

机构信息

Cátedra de Cardiología, Universidad del País Vasco, Bilbao, España.

出版信息

Arch Inst Cardiol Mex. 1995 Sep-Oct;65(5):444-52.

PMID:8678701
Abstract

Hypertensive cardiomyopathies can be divided into 4 ascending categories according to the pathophysiologic and clinical impact of hypertension on the heart: Grade I. This category is characterized by LV diastolic dysfunction with no associated LV hypertrophy. Grade II. Patients at this stage present LV diastolic dysfunction with echocardiographic LV hypertrophy. Exercise capacity in terms of maximal oxygen consumption may be normal (Grade IIA) o impaired (Grade IIB). Grade III. This stage is distinguished by the presence of congestive heart failure (severe dyspnea and X-ray pulmonary edema with normal EF (> or = 50%). Patients having LV mass/volume ratio > 1.8 with little or no myocardial ischemia are classified as IIIA, as compared with IIIB patients having LV mass/volume ratio < 1.8 and significant myocardial ischemia. Clinically, these two subgroups can be distinguished as follows: the presence of a fourth sound and the absence of cardiomegaly for classification as IIIA, and a third sound plus cardiomegaly for classification as IIIB. Grade IV. Here the profile is one of dilated cardiomyopathy, LV hypertrophy and impaired EF (< 50%). The 5-year mortality rate is higher for Grade IV patients than for Grade III patients, although the morbility rate is similar in both.

摘要

根据高血压对心脏的病理生理和临床影响,高血压性心肌病可分为4个递进类别:I级。此类别以左心室舒张功能障碍且无相关左心室肥厚为特征。II级。此阶段患者表现为左心室舒张功能障碍且超声心动图显示左心室肥厚。就最大耗氧量而言,运动能力可能正常(IIA级)或受损(IIB级)。III级。此阶段的特征是存在充血性心力衰竭(严重呼吸困难和X线显示肺水肿且射血分数正常(≥50%))。左心室质量/容积比>1.8且几乎没有或没有心肌缺血的患者归类为IIIA级,与之相比,左心室质量/容积比<1.8且有明显心肌缺血的患者为IIIB级。临床上,这两个亚组可按以下方式区分:存在第四心音且无心脏扩大的归类为IIIA级,存在第三心音且有心脏扩大的归类为IIIB级。IV级。此阶段的特征是扩张型心肌病、左心室肥厚且射血分数受损(<50%)。IV级患者的5年死亡率高于III级患者,尽管两者的发病率相似。

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