Valenta R, Kraft D
University of Vienna, Austria.
Curr Opin Immunol. 1995 Dec;7(6):751-6. doi: 10.1016/0952-7915(95)80043-3.
A considerable number of cDNAs coding for allergens have been isolated and expressed. Structural and immunological similarities between recombinant allergens and natural allergens indicate that a sufficient panel of recombinant allergens can be produced for diagnosis and therapy of allergic diseases. Recent studies document the successful in vitro and in vivo determination of a patient's allergen profile (allergogram) with recombinant allergens and encourage the use of recombinant allergens for specific therapy.
大量编码变应原的cDNA已被分离和表达。重组变应原与天然变应原之间的结构和免疫学相似性表明，可为过敏性疾病的诊断和治疗制备足够的重组变应原组。最近的研究证明了利用重组变应原在体外和体内成功测定患者的变应原谱（变应原图），并鼓励将重组变应原用于特异性治疗。
