Middelweerd M J, de Vries N, Calliauw J, van Kamp G J
Department of Otorhinolaryngology/Head & Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
Eur Arch Otorhinolaryngol. 1995;252(6):336-9. doi: 10.1007/BF00178272.
A new method for the detection of cerebrospinal fluid (CSF) leakage is described, and is a refinement of the method originally reported by Oberascher and Arrer in 1986. Immuno-electrophoretic measurements are performed in a two-buffer system, making the test easier to do and providing qualitatively better images. Genetic variants of transferrin (which has a general population incidence of 2-4%) can be discriminated from false-positive test results in affected families. The test described is recommended as the method of choice for initial screening of suspected CSF leakage.
本文描述了一种检测脑脊液（CSF）漏的新方法，它是对奥伯拉舍尔和阿雷尔于1986年最初报道的方法的改进。免疫电泳测量在双缓冲系统中进行，使测试操作更简便，并能提供质量更好的图像。转铁蛋白的基因变异（在普通人群中的发生率为2%-4%）可与受影响家族中的假阳性检测结果相区分。所描述的检测方法被推荐为疑似脑脊液漏初始筛查的首选方法。
