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鼻炎患者鼻腔黏液的流变学特征。

The rheological characteristics of nasal mucus in patients with rhinitis.

作者信息

Passàli D, Bellussi L, Lauriello M

机构信息

Istituto di discipline Otorinolaryngologiche, Università degli Studi di Siena, Policlinico Le Scotte, Italy.

出版信息

Eur Arch Otorhinolaryngol. 1995;252(6):348-52. doi: 10.1007/BF00178275.

Abstract

In this paper we have analyzed the physical properties of nasal mucus from 120 outpatients with rhinitis. We focused on the most relevant rheological features: viscosity, elasticity, adhesiveness, as well as ability to be spun ("spinability") or poured ("pourability"). A double-capillary type viscometer was used to measure viscosity and elasticity and the platinum ring method to measure adhesiveness. "Spinability" was measured with an automatic apparatus (Filancemetre Sefam) and "pourability" was determined by describing flow under gravity. Efficacy of nasal clearance was analyzed by measuring mucociliary transport time with an inert tracer using vegetal charcoal powder. Results showed that impaired nasal mucosal function in patients with rhinitis could be determined by studying rheological features in addition to measuring mucociliary activity. Information provided proved invaluable when considering possible treatment with agents affecting kinesis of nasal mucus.

摘要

在本文中,我们分析了120例鼻炎门诊患者鼻黏液的物理特性。我们重点关注了最相关的流变学特征:黏度、弹性、黏附性,以及可纺性(“spinnability”)或可倒性(“pourability”)。使用双毛细管型黏度计测量黏度和弹性,用铂环法测量黏附性。用自动仪器(Filancemetre Sefam)测量“可纺性”,通过描述重力作用下的流动来确定“可倒性”。通过使用植物炭粉作为惰性示踪剂测量黏液纤毛运输时间来分析鼻腔清除效率。结果表明,除了测量黏液纤毛活性外,通过研究流变学特征也可以确定鼻炎患者鼻黏膜功能受损情况。在考虑使用影响鼻黏液运动的药物进行可能的治疗时,所提供的信息被证明具有极高的价值。

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