Jung G M, Wagner J P, Ernest O, Schneegans O, Gentine A
Département de radiothérapie, Strasbourg, France.
Bull Cancer Radiother. 1996;83(1):34-9.
In a series of 224 patients treated between 1980 and 1992 for hypopharyngeal carcinoma by surgery and post postoperative radiotherapy we found an overall 54% incidence of elevated TSH levels. Decreased FT4 levels were associated in about one-third of the patients. When thyroidectomy was performed, 71% of the patients developed thyroid dysfunction. Most TSH abnormalities (45%) occurred within two years of treatment. Nevertheless, long-term followup is indicated since those complications may be delayed. Hormonal replacement therapy is recommended for patients with elevated TSH.
在1980年至1992年间接受手术及术后放疗治疗下咽癌的224例患者中，我们发现促甲状腺激素（TSH）水平升高的总体发生率为54%。约三分之一的患者伴有游离甲状腺素（FT4）水平降低。行甲状腺切除术后，71%的患者出现甲状腺功能障碍。大多数TSH异常（45%）发生在治疗后的两年内。然而，鉴于这些并发症可能会延迟出现，仍需进行长期随访。对于TSH升高的患者，建议进行激素替代治疗。
