Lu R B, Ko H C, Chang F M, Castiglione C M, Schoolfield G, Pakstis A J, Kidd J R, Kidd K K
Department of Psychiatry, Tri-Service General Hospital, National Defence Medical Center, Taipei, Taiwan, Republic of China.
Biol Psychiatry. 1996 Mar 15;39(6):419-29. doi: 10.1016/0006-3223(95)00182-4.
This study examined whether there is evidence for an association between alcoholism and the alleles of the TaqI A, TaqI B, and short tandem repeat polymorphisms (STRP), both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2) in males of three populations from Taiwan. We studied 46 Chinese Han (21 alcoholics and 25 nonalcoholics), 42 Atayal (21 alcoholics and 21 nonalcoholics), and 40 Ami (20 alcoholics and 20 nonalcoholics). Alcoholism was diagnosed according to DSM-III-R criteria and all individuals in the alcoholic groups were severely affected. Significant linkage disequilibrium occurs for the three polymorphic sites in all three populations. No significant association was observed between any of the three polymorphisms at the DRD2 locus, tested individually and as haplotypes, and alcoholism in the three subject groups. We conclude that no association exists between genetic variation at the DRD2 locus and alcoholism in Chinese Han, Atayal, and Ami males.
本研究调查了台湾三个群体的男性中，酗酒与多巴胺D2受体基因（DRD2）的TaqI A、TaqI B等位基因以及短串联重复多态性（STRP）之间是否存在关联，包括单个基因座以及单倍型形式。我们研究了46名中国汉族男性（21名酗酒者和25名非酗酒者）、42名泰雅族男性（21名酗酒者和21名非酗酒者）以及40名阿美族男性（20名酗酒者和20名非酗酒者）。酗酒根据《精神疾病诊断与统计手册》第三版修订版（DSM-III-R）标准进行诊断，酗酒组的所有个体均受到严重影响。在所有三个群体中，这三个多态性位点均存在显著的连锁不平衡。在DRD2基因座的三个多态性位点中，无论是单独检测还是作为单倍型检测，在三个受试组中均未观察到与酗酒有显著关联。我们得出结论，在汉族、泰雅族和阿美族男性中，DRD2基因座的遗传变异与酗酒之间不存在关联。
