Pardell H, Salto E, Ciruela J, Tresserras R, Gascon P, Salleras L
Departamento de Sanidad y Seguridad Social, Generalitat de Catalunya, Barcelona.
An Med Interna. 1996 Jan;13(1):16-20.
Smoking abstinence rates of a group of 300 physicians and pharmacists of Catalonia (Spain) who participated in an open non-controlled follow-up design study with nicotine patch, are presented. Were eligible all the individuals who regularly smoke more than 15 cigarettes/day and get Fagerström Test score of 5 or more. Those who smoke more than 20 cig/day were offered a 3-month 24-hour transdermal nicotine treatment (30-20-10 schedule) and those smoking between 15 and 20 cig/day, received the 20-20-10 schedule. A follow up of participants was carried out at 3, 6, 9 and 12 months. After one year, 12 participants (4%) were dropped out. The overall abstinence rates at 3, 6, 9 and 12 months were respectively 55.9% (IC95%: 50.2-61.6), 42.7% (IC95%: 37.0-48.4), 35.4% (IC95% 29.9-40.9), 33.7% (IC95%: 28.2-39.2). Among predictive cessation variables, only those who had mad 1 to 3 previous attempts and those with only "cold turkey" (or slow reduction) quit experience, obtained statistically better results at 3 months. These results seem to be as good as or even better than those obtained in other similar studies with nicotine patch.
本文呈现了一组来自加泰罗尼亚（西班牙）的300名医生和药剂师的戒烟率，他们参与了一项使用尼古丁贴片的开放性非对照随访设计研究。所有每天规律吸烟超过15支且法格斯特罗姆测试得分在5分及以上的个体均符合条件。每天吸烟超过20支的人接受了为期3个月的24小时经皮尼古丁治疗（30 - 20 - 10方案），而每天吸烟15至20支的人则接受20 - 20 - 10方案。在3、6、9和12个月时对参与者进行了随访。一年后，有12名参与者（4%）退出。在3、6、9和12个月时的总体戒烟率分别为55.9%（95%置信区间：50.2 - 61.6）、42.7%（95%置信区间：37.0 - 48.4）、35.4%（95%置信区间29.9 - 40.9）、33.7%（95%置信区间：28.2 - 39.2）。在预测戒烟的变量中，只有那些之前有过1至3次尝试以及只有“突然戒烟”（或缓慢减量）戒烟经历的人，在3个月时取得了统计学上更好的结果。这些结果似乎与其他使用尼古丁贴片的类似研究中获得的结果一样好，甚至更好。
