Richards P, Jones M B, Peart W S
Gut. 1973 Jun;14(6):478-84. doi: 10.1136/gut.14.6.478.
A 47-year-old woman was cured of hypokalaemia and recurrent paralysis by the excision of an adrenal adenoma. Hypertension was initially ameliorated but was not cured. Suppression of plasma renin activity was abolished when the adenoma was excised. Repeated measurement of plasma corticosteroids before operation showed a slight increase in aldosterone and normal plasma concentrations of deoxycorticosterone, corticosterone, and cortisol. No evidence of excess mineralocorticoid was obtained from measurement of the electrolyte composition of colonic fluid or of rectal potential difference, although both these variables responded normally to salt depletion and exogenous aldosterone. The diagnostic importance of the paradoxically normal colonic measurements is emphasized and the possibility is considered that the adenoma may have secreted an unidentified hormone.
一名47岁女性因肾上腺腺瘤切除而治愈低钾血症和反复瘫痪。高血压最初有所改善但未治愈。切除腺瘤后，血浆肾素活性的抑制作用消失。术前反复测量血浆皮质类固醇显示醛固酮略有升高，而脱氧皮质酮、皮质酮和皮质醇的血浆浓度正常。尽管结肠液电解质组成和直肠电位差这两个变量对盐耗竭和外源性醛固酮的反应正常，但通过测量未发现盐皮质激素过多的证据。强调了结肠测量结果反常正常的诊断重要性，并考虑了腺瘤可能分泌了一种未鉴定激素的可能性。
