Fujishima N
First Department of Pathology, Hyogo College of Medicine, Japan.
J Gastroenterol. 1996 Apr;31(2):207-13. doi: 10.1007/BF02389519.
The proliferative activity of serrated adenomas of the large intestine was determined by examining proliferating cell nuclear antigen (PCNA). The PCNA labeling index, determined by visual inspection, and the PCNA area rate, determined with the newly developed image processor for analytical pathology (IPAP), of serrated adenoma were found to be similar to the values for tubular adenoma, and indicated the presence of high proliferative activity in the bottoms of crypts. Determination of the pattern of distribution of PCNA-positive cells indicated the presence of a proliferative zone in the lower region or bottom of the serrated adenoma. However, 5 of the 20 serrated adenomas exhibited an irregular on widely extended proliferative zone, and 2 were complicated by cancer. These findings indicated that serrated adenoma is also a highly proliferative tumor and that it may be complicated by cancer if atypia is increased and disturbance of the proliferative zone is present.
通过检测增殖细胞核抗原（PCNA）来确定大肠锯齿状腺瘤的增殖活性。经目视检查确定的PCNA标记指数以及用新开发的用于分析病理学的图像处理器（IPAP）测定的PCNA面积率，发现锯齿状腺瘤与管状腺瘤的值相似，表明隐窝底部存在高增殖活性。PCNA阳性细胞分布模式的测定表明在锯齿状腺瘤的下部区域或底部存在增殖区。然而，20个锯齿状腺瘤中有5个表现出不规则或广泛扩展的增殖区，2个合并有癌症。这些发现表明，锯齿状腺瘤也是一种高增殖性肿瘤，如果异型性增加且增殖区出现紊乱，可能会合并癌症。
