Holmes M D, Ojemann G A, Lettich E
Department of Medicine Neurology, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104, USA.
Brain Res. 1996 Mar 4;711(1-2):44-9. doi: 10.1016/0006-8993(95)01351-2.
Neuronal activity was recorded extracellularly from 22 neurons in the right lateral temporal cortex of 12 patients undergoing awake craniotomy for surgical treatment of epilepsy during tests of visuospatial function. These included: measures of short-term visuospatial memory; face, complex figure and line matching; labeling of facial emotional expressions; and a language task, object naming. Six neurons demonstrated significant changes during one or more of the three 1.3-s epochs following test presentation. All 6 of these neurons demonstrated inhibition during short-term visuospatial memory entry, or retrieval, or both. Four of the neurons also showed significant changes during one or more matching tasks; 8 of 10 of these changes were excitatory. One neuron also demonstrated excitation with labeling of facial emotional expression and another with naming. These data demonstrate in human right lateral temporal cortex a pattern of inhibition of neuronal activity during short-term visuospatial memory that contrasts with excitation during other functions, particularly figure matching.
在对12例接受清醒开颅手术治疗癫痫的患者进行视觉空间功能测试期间，从其右侧颞叶皮质的22个神经元进行了细胞外神经元活动记录。这些测试包括：短期视觉空间记忆测量；面部、复杂图形和线条匹配；面部表情标记；以及一项语言任务，即物体命名。在测试呈现后的三个1.3秒时间段中的一个或多个时间段内，有6个神经元表现出显著变化。所有这6个神经元在短期视觉空间记忆输入、检索或两者过程中均表现出抑制。其中4个神经元在一项或多项匹配任务中也表现出显著变化；这些变化中的10个有8个是兴奋性的。一个神经元在面部表情标记时表现出兴奋，另一个在命名时表现出兴奋。这些数据表明，在人类右侧颞叶皮质中，短期视觉空间记忆期间神经元活动受到抑制，这与其他功能（特别是图形匹配）期间的兴奋形成对比。
