Coulter W A, McGimpsey J G, Coffey A, Strawbridge J, Linden G J
Department of Restorative Dentistry, Queen's University of Belfast, Northern Ireland.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Dec;80(6):660-5. doi: 10.1016/s1079-2104(05)80247-1.
Erythromycin stearate is an acid labile antibiotic, therefore fear and apprehension, which are known to affect gastric motility, may produce erratic absorption resulting in lower serum levels. The mean (SD) serum erythromycin concentration 75 minutes after a 1.5 gm oral dose of erythromycin stearate to 45 patients was 8.7 (4.8) mg/L and ranged widely from 0.4 to 20.5 mg/L. The serum concentration of erythromycin was below therapeutic levels (1.0 mg/L) in two patients. No significant association was found between anxiety and serum levels of erythromycin when age, gender, and gastric distress were taken into account. It is concluded that dental anxiety may indirectly influence the uptake of oral erythromycin stearate; but this relationship is complex, and there is no evidence from this study that increased dental anxiety decreases the uptake of the drug.
硬脂酸红霉素是一种对酸不稳定的抗生素，因此，已知会影响胃动力的恐惧和忧虑可能会导致吸收不稳定，从而使血清水平降低。对45名患者口服1.5克硬脂酸红霉素后75分钟，血清红霉素浓度的平均值（标准差）为8.7（4.8）毫克/升，范围在0.4至20.5毫克/升之间。两名患者的红霉素血清浓度低于治疗水平（1.0毫克/升）。在考虑年龄、性别和胃部不适因素后，未发现焦虑与红霉素血清水平之间存在显著关联。得出的结论是，牙科焦虑可能间接影响口服硬脂酸红霉素的吸收；但这种关系很复杂，本研究没有证据表明牙科焦虑增加会降低药物的吸收。
