Sefton A M, Maskell J P, Kerawala C, Cannell H, Seymour A, Sun Z M, Williams J D
Department of Medical Microbiology, London Hospital Medical College, UK.
J Antimicrob Chemother. 1990 Jun;25(6):975-84. doi: 10.1093/jac/25.6.975.
The tolerance and pharmacokinetics of erythromycin stearate and josamycin base were compared in healthy dental students. The efficacy and tolerance of the two antibiotics were compared in the prevention of bacteraemia following dental extraction. Erythromycin achieved higher serum levels at the time of extraction in dental patients than did josamycin. Erythromycin was rapidly and better absorbed than josamycin in the student volunteers, but josamycin caused less gastrointestinal side effects than erythromycin. Both antibiotics were only marginally more effective than placebo in preventing bacteraemia following dental extraction.
在健康牙科专业学生中比较了硬脂酸红霉素和交沙霉素碱的耐受性及药代动力学。比较了这两种抗生素在预防拔牙后菌血症方面的疗效和耐受性。在牙科患者拔牙时，红霉素的血清水平高于交沙霉素。在学生志愿者中，红霉素比交沙霉素吸收更快且更好，但交沙霉素引起的胃肠道副作用比红霉素少。在预防拔牙后菌血症方面，两种抗生素仅比安慰剂略有效。
