Niederman R, Naleway C, Lu B Y, Buyle-Bodin Y, Robinson P
Forsyth Dental Center, Boston, MA, USA.
J Clin Periodontol. 1995 Oct;22(10):804-9. doi: 10.1111/j.1600-051x.1995.tb00264.x.
Elevated temperature is one of 4 cardinal inflammatory signs. Previous work indicates that subgingival temperature assessments are accurate and re- liable, and provide objective, quantitative information over a broad 10 degrees C range, in small 0.1 degrees C increments with a direct, immediate report on the inflammatory status at the pocket base. However, complicating the use and interpretation of subgingival temperature assessments are its 3 forms: actual subgingival temperature, sublingual temperature minus subgingival temperature (temperature differential), and a temperature indicator light. We reasoned that if one could determine which of the temperature assessments reflected the periodontal condition, and which were independent variables, they would provide new and unique information about the inflammatory status of the periodontium. We also reasoned that by providing objective, quantitative data over a broad range, subgingival temperature should reduce the sample size required to obtain significance in clinical trials. Therefore, the purpose of this study was 2-fold: (1) to determine whether the 3 subgingival temperature assessments could differentiate between clinically defined periodontal health and disease; (2) to determine whether the 3 assessments were dependent or independent clinical variables. The data indicated that all 3 subgingival temperature assessment methods differentiated between clinically-defined periodontal health and disease (all p<0.02). All 3 assessments also correlated significantly (all p<0.03), but modestly (all r>0.49), with bleeding on probing. Based on scatter-plot matrices and common factor analysis, the data indicated that only actual subgingival temperature and temperature differential were independent variables. Taken together, this data indicates that subgingival temperature and temperature differential provide unique information about the periodontal inflammatory state. Power calculations indicated that the temperature differential may significantly reduce the subject number required to achieve significance in clinical trials examining gingival inflammation. Because of the body's rapid temperature response, these assessments may also significantly reduce the time required for gingival inflammation trials.
体温升高是四种主要炎症体征之一。先前的研究表明，龈下温度评估准确可靠，能在10摄氏度的广泛范围内以0.1摄氏度的微小增量提供客观、定量的信息，并能直接即时报告牙周袋底部的炎症状态。然而，龈下温度评估的三种形式使该评估的使用和解读变得复杂：实际龈下温度、舌下温度减去龈下温度（温度差）以及温度指示灯。我们推断，如果能够确定哪种温度评估反映牙周状况，哪些是独立变量，它们将提供有关牙周组织炎症状态的全新且独特的信息。我们还推断，通过在广泛范围内提供客观、定量的数据，龈下温度应能减少临床试验中达到显著性所需的样本量。因此，本研究的目的有两个：（1）确定三种龈下温度评估能否区分临床定义的牙周健康和疾病；（2）确定这三种评估是相关还是独立的临床变量。数据表明，所有三种龈下温度评估方法都能区分临床定义的牙周健康和疾病（所有p<0.02）。所有三种评估也都与探诊出血显著相关（所有p<0.03），但相关性中等（所有r>0.49）。基于散点图矩阵和共同因子分析，数据表明只有实际龈下温度和温度差是独立变量。综上所述，这些数据表明龈下温度和温度差提供了有关牙周炎症状态的独特信息。功效计算表明，温度差可能会显著减少在检查牙龈炎症的临床试验中达到显著性所需的受试者数量。由于身体的快速温度反应，这些评估也可能显著减少牙龈炎症试验所需的时间。
