Bösche J, Gelbke H P
Z Rechtsmed. 1977 Apr 18;79(3):235-40. doi: 10.1007/BF00200499.
In 12 cases of fatal poisoning with morphine or heroin a radioimmunological determination of morphine was carried out in vitreous humor, cerebrospinal fluid and urine. The concentrations varied between 30 and 350 ng of morphine-equivalents/ml in the cerebrospinal fluid and between 45 and 280 ng/ml in the vitreous humor (urine concentrations: 120-100.000 ng/ml). The counts per minute differed significantly for samples with and without prior ingestion of morphine, when vitreous and cerebrospinal fluids were tested by the morphine (3H) radioimmunoassay. Thereby it was clearly demonstrated, that radioimmunoassay is a valuable screening procedure for the rapid identification of morphine in corpses, even when urine is not available.
在12例因吗啡或海洛因导致的致命中毒案例中，对玻璃体液、脑脊液和尿液进行了吗啡的放射免疫测定。脑脊液中吗啡当量的浓度在30至350纳克/毫升之间，玻璃体液中为45至280纳克/毫升（尿液浓度：120至100,000纳克/毫升）。当用吗啡（3H）放射免疫分析法检测玻璃体液和脑脊液时，事先摄入吗啡和未摄入吗啡的样本每分钟计数有显著差异。由此清楚地表明，即使没有尿液，放射免疫分析也是快速鉴定尸体中吗啡的有价值的筛查方法。
