多元醇对沙鼠味觉感受器的刺激。

Stimulation of the gerbil's gustatory receptors by polyols.

作者信息

Jakinovich W, Oakley B

出版信息

Brain Res. 1976 Jul 16;110(3):505-13. doi: 10.1016/0006-8993(76)90861-1.

Abstract

The gustatory responses of the Mongolian gerbil were tested with 12 sugar alcohols. The electrophysiological effectiveness of the linear polyols as gustatory stimulants increased as the length of the carbon chain increased from 2 to 5. Six and 7 carbon acyclic polyols were no more effective than the pentitols. By comparison myoinositol, a cyclic polyol, was more effective in evoking a response. Responses to mixtures of D-sorbitol and sucrose suggest that these sugars compete for a common receptor site. A sucrose receptor site and a model of it is proposed.

摘要

用12种糖醇测试了蒙古沙鼠的味觉反应。随着碳链长度从2增加到5，线性多元醇作为味觉刺激剂的电生理有效性增强。含有6个和7个碳原子的无环多元醇的有效性并不比戊糖醇更高。相比之下，环状多元醇肌醇在引发反应方面更有效。对D-山梨醇和蔗糖混合物的反应表明，这些糖类竞争共同的受体位点。本文提出了一个蔗糖受体位点及其模型。