King A I, Ruan J S, Zhou C, Hardy W N, Khalil T B
Bioengineering Center, Wayne State University, Detroit, Michigan, USA.
J Neurotrauma. 1995 Aug;12(4):651-8. doi: 10.1089/neu.1995.12.651.
Biomechanics of cerebral trauma attempts to delineate the dynamic response of the cranial vault contents to a direct or indirect impact to the head. Consequently, brain injury mechanisms and associated tolerance to impact can be deduced by establishing a relationship between neurological deficit and mechanical dosage. The resulting information is invaluable to brain injury prevention and diagnosis. This paper presents an overview of our recent research on head injury focusing on establishing brain injury biomechanics by developing a comprehensive and validated mathematical model. To achieve our goal, we developed a comprehensive three-dimensional finite element human head model, finite element porcine head models, and sensors to monitor head kinematics and brain strains by neutral density accelerometers. The information obtained from this research thus far provided a predictive and somewhat validated mathematical model of the head, which clearly shows a correspondence between brain mechanical response and experimentally observed injuries.
脑外伤生物力学试图描绘颅腔内容物对头部直接或间接撞击的动态反应。因此，通过建立神经功能缺损与机械剂量之间的关系，可以推断出脑损伤机制及相关的撞击耐受性。所得信息对于脑损伤的预防和诊断非常宝贵。本文概述了我们最近关于头部损伤的研究，重点是通过开发一个全面且经过验证的数学模型来建立脑损伤生物力学。为实现我们的目标，我们开发了一个全面的三维有限元人体头部模型、有限元猪头部模型以及用于通过中性密度加速度计监测头部运动学和脑应变的传感器。迄今为止从这项研究中获得的信息提供了一个具有预测性且在一定程度上经过验证的头部数学模型，该模型清楚地显示了脑机械反应与实验观察到的损伤之间的对应关系。
