日本葡萄球菌菌株对金属和抗生素的耐药性分布
Distribution of resistances to metals and antibiotics of staphylococcal strains in Japan.
作者信息
Nakahara H, Ishikawa T, Sarai Y, Kondo I
出版信息
Zentralbl Bakteriol Orig A. 1977 Apr;237(4):470-6.
Clinical isolates of 565 staphylococcal strains were studied for the resistance to four metals and eight antibiotics. Distribution patterns of their susceptibilities to Hg, As and Pb clearly revealed two peaks. But in the case of Cd resistance, there were three groups of Cd sensitivity. Frequencies of metal resistances were 36.6% to Hg, 95.6% to Cd, 48.8% to As and 91.9% to Pb. On the other hand, those of drug resistances were 87.3% to PC, 28.5% to SM, 33.5% to TC, 22.7% to CP, 23.9% to KM, 43.0% to EM, 38.8% to JM and 0% to GM. Most of tested cultures were metal-resistant (92.9%), moreover, these multiple-metal-resistant strains were also found to be multiple-drug-resistant. And about 10% of total isolates were metal-resistant and drug-senstitive strains, whereas the frequency of the metal-sensitive and drug-resistant strains was only 1.8%.
对565株葡萄球菌临床分离株进行了对四种金属和八种抗生素的耐药性研究。它们对汞、砷和铅的敏感性分布模式明显显示出两个峰值。但在镉抗性方面，有三组镉敏感性。金属抗性频率分别为：对汞36.6%、对镉95.6%、对砷48.8%、对铅91.9%。另一方面，药物抗性频率分别为：对青霉素87.3%、对链霉素28.5%、对四环素33.5%、对氯霉素22.7%、对卡那霉素23.9%、对红霉素43.0%、对洁霉素38.8%、对庆大霉素0%。大多数测试培养物对金属耐药（92.9%），此外，这些多重金属耐药菌株也被发现具有多重耐药性。约10%的总分离株是金属耐药且对药物敏感的菌株，而金属敏感且耐药的菌株频率仅为1.8%。
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