[慢性酒精中毒的发病机制]
[Pathogenesis of chronic alcohosim].
作者信息
Danilenko A M
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(4):579-83.
The paper is concerned with a study of the enzyme activity which reflects the functional state of the liver in 123 patients with chronic alcoholism (without clinical signs of disturbed liver function). The blood serum was studied for sorbitdehydrogenase, frutose-I-phosphataldolase, glutamino-asparagine and glutamine-alanine transamine. It was established that there is an increase in the activity of specific and nonspecific liver enzymes. This increase was in a direct correlation with the clinical expression and severity of the disease (withdrawal syndrome, delirious condition). It is being concluded that the indices of the level of enzyme activity may be used for the evaluation of the state of the patients and its change under the effect of treatment.
该论文关注对123例慢性酒精中毒患者（无肝功能紊乱临床体征）肝脏功能状态的酶活性研究。对血清进行了山梨醇脱氢酶、果糖-1-磷酸醛缩酶、谷氨酰胺-天冬酰胺和谷氨酰胺-丙氨酸转氨酶的检测。结果表明，特异性和非特异性肝脏酶的活性均有所增加。这种增加与疾病的临床表现和严重程度（戒断综合征、谵妄状态）直接相关。得出结论，酶活性水平指标可用于评估患者状态及其在治疗作用下的变化。
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