Vijayalaxmi K K, Rai S P
Department of Studies in Applied Zoology, Mangalore University, India.
Mutat Res. 1996 Jun 12;368(2):109-14. doi: 10.1016/0165-1218(95)00101-8.
The genotoxic effects of tamoxifen citrate, an anti-oestrogenic drug, were studied using mouse bone marrow chromosome aberration assay (CA) and micronucleus (MN) test. The dose and time yield effects of the drug were investigated after repeated administration of various doses of the drug for 10 days. The doses used were, 0.1, 0.2, 0.4 and 0.8 mg/kg/day. Bone marrow preparations were made at 24, 48, 72 and 96 h after the last administration. The anticancer drug cyclophosphamide (CP) at a dose of 100 mg/kg was used as positive control. A statistically significant chromosomal aberration and MN induced by tamoxifen revealed its clastogenic potency.
