Asayama K, Hayashibe H, Mishiku Y, Honda M, Ito H, Nakazawa S
Department of Pediatrics, Yamanashi Medical University, Japan.
Nephron. 1996;72(2):231-6. doi: 10.1159/000188847.
The activity of cholesteryl ester transfer protein (CETP) was assayed in sera of children and adolescents on continuous ambulatory peritoneal dialysis (CAPD) by coincubating lipoprotein-deficient samples with exogenous donor and acceptor lipoproteins. Serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio were increased, while the high-density lipoprotein cholesterol level was decreased. The CETP activity in children on CAPD exceeded that in either adults or control children, and was correlated with low-density lipoprotein cholesterol, apolipoprotein B, and total cholesterol/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol, and apolipoprotein B/apolipoprotein A1 ratios. The CETP activity in CAPD patients may be due to increased synthesis in response to a protein loss in the dialysis fluid and may exacerbate atherosclerosis.
通过将脂蛋白缺乏的样本与外源性供体和受体脂蛋白共同孵育，对接受持续非卧床腹膜透析（CAPD）的儿童和青少年血清中的胆固醇酯转运蛋白（CETP）活性进行了测定。血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B水平以及载脂蛋白B/载脂蛋白A1比值升高，而高密度脂蛋白胆固醇水平降低。接受CAPD治疗的儿童的CETP活性超过成人或对照儿童，且与低密度脂蛋白胆固醇、载脂蛋白B以及总胆固醇/高密度脂蛋白胆固醇、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇和载脂蛋白B/载脂蛋白A1比值相关。CAPD患者的CETP活性可能是由于对透析液中蛋白质丢失的反应性合成增加所致，并且可能会加重动脉粥样硬化。
