Zarcone R, Bellini P, Cardone G, Barletta E, Vicinanza G
II Università degli Studi, Napoli.
Minerva Ginecol. 1996 Mar;48(3):111-3.
At present the therapy of cervical condylomatosis is based on the use of interferon because the HPV types responsable for condyloma inhibit the immunitary system. But many A. studying the effects of IFN have found that at high concentration it has an immunosuppressive action. The aim of the present study was to evaluate if interleukin-2 associated with IFN is useful in avoiding this negative effect by improving the efficacy of cervical condylomatosis therapy. We treated 25 women suffering from cervical condyloma with increasing doses of IL-2 injected intralesionally and associated with natural alpha-IFN injected intramuscularly. The duration of the whole therapy was six weeks. We evaluated the percentage of inflammatory cells in peripheral blood before and after treatment. The per-cent number of lymphocytes, eosinophils and lymphoblasts was increased by 27%, 88% and 40%, respectively. The clinical response to the therapy was total in 14 cases, partial in 9 cases and unsuccessful in 2 cases. These data suggested that combination therapy with interleukin-2 and alpha-IFN for the treatment of patients with cervix condylomatous is successful.
目前，宫颈湿疣的治疗基于干扰素的使用，因为导致湿疣的人乳头瘤病毒（HPV）类型会抑制免疫系统。但是许多研究干扰素作用的人发现，高浓度时它具有免疫抑制作用。本研究的目的是评估白细胞介素-2与干扰素联合使用是否有助于通过提高宫颈湿疣治疗的疗效来避免这种负面影响。我们用递增剂量的白细胞介素-2进行皮损内注射，并联合天然α-干扰素进行肌肉注射，治疗了25例患有宫颈湿疣的女性。整个治疗持续六周。我们评估了治疗前后外周血中炎症细胞的百分比。淋巴细胞、嗜酸性粒细胞和淋巴母细胞的百分比分别增加了27%、88%和40%。治疗的临床反应为14例完全缓解，9例部分缓解，2例无效。这些数据表明，白细胞介素-2和α-干扰素联合治疗宫颈湿疣患者是成功的。
