Zarcone R, Bellini P, Cardone G, Cardone A
Department of Obstetrics and Gynecology, Second University of Naples, Italy.
Clin Exp Obstet Gynecol. 1995;22(4):326-9.
The main viruses responsible for condyloma, a venereal disease, are the HPV 16 and 11. The stages of HPV infection are under the control of the immunitary system, which is inhibited by the virus itself. For this reason, the therapy of cervical condylomatosis is, at present, based on the use of interferon. The purpose of this study was to appreciate the activation of the immune system after therapy with interferon. We treated 12 women suffering from cervical condyloma and exocervical CIN with increasing doses of natural alpha-IFN injected intramuscularly, and also applied to the vagina. The clinical response to the therapy was total in 7 cases, partial in 4 cases and unsuccessful in I case. We also evaluated the percentage of inflammatory cells in the peripheral blood and at the level of the condylomatous lesions, After treatment the absolute and percentage number of inflammatory cells increased. Besides, at the level of the lesion the CD1 and CD4 cells also increased.
引起尖锐湿疣（一种性病）的主要病毒是HPV 16和11。HPV感染的阶段受免疫系统控制，而免疫系统会被病毒本身抑制。因此，目前宫颈湿疣的治疗基于干扰素的使用。本研究的目的是评估干扰素治疗后免疫系统的激活情况。我们对12名患有宫颈湿疣和宫颈外CIN的女性进行治疗，肌肉注射并阴道给药递增剂量的天然α-干扰素。治疗的临床反应7例为完全缓解，4例为部分缓解，1例无效。我们还评估了外周血和湿疣病变部位的炎症细胞百分比。治疗后，炎症细胞的绝对数量和百分比均增加。此外，在病变部位，CD1和CD4细胞也增加。
