Zarcone R, Bellini P, Carfora E, Monarca M, Vicinanza G, Cardone A
2nd University, Department of Obstetrics and Gynecology, Naples, Italy.
Clin Exp Obstet Gynecol. 1997;24(2):93-4.
The stages of HPV (Human Papilloma Virus) infection are under the control of the immune system, which is inhibited by the virus itself. Thus, at present the treatment of condyloma acuminata is based on the use of interferon (IFN). The aim of the present study was to evaluate immune system activation and clinical response to IFN therapy. In addition, in the most serious cases, medical treatment with IFN was associated with diathermocoagulation (DTC) of persistent warts. The effectiveness of the combined therapy was also assessed.
7 women (age range: 16-52) suffering from cervix condylomata were selected for our study. All of them were injected intramuscularly with doses of 3 million UI of IFN-alpha leucocytar every three days for six weeks together with daily applications of alpha-IFN for six weeks. The women that were still ill three months after IFN therapy, were treated with DTC. In one case, another cycle of IFN treatment was necessary.
Clinical response to IFN treatment was complete in 46 cases, partial in 20 cases and unsuccessful in 4 cases. After three months of medical therapy, 30 women were treated with DTC. After this therapy, in 21 cases, the warts were resolved. After 24 months the percentage of relapse was 37.9% when only IFN was used, and 4.51% when IFN was combined with DTC.
These data suggest that a successful protocol for the treatment of condyloma acuminata consist of IFN therapy associated with DTC when warts persisted.
人乳头瘤病毒（HPV）感染的阶段受免疫系统控制，但该病毒本身会抑制免疫系统。因此，目前尖锐湿疣的治疗基于使用干扰素（IFN）。本研究的目的是评估免疫系统激活情况以及对IFN治疗的临床反应。此外，在最严重的病例中，IFN药物治疗与持续性疣体的透热凝固术（DTC）联合使用。同时也评估了联合治疗的有效性。
我们选择了7名患有宫颈湿疣的女性（年龄范围：16 - 52岁）进行研究。她们均每三天肌肉注射300万国际单位的白细胞α干扰素，持续六周，同时每天应用α干扰素，持续六周。IFN治疗三个月后仍患病的女性接受DTC治疗。有1例患者需要进行另一个IFN治疗周期。
IFN治疗的临床反应中，46例完全缓解，20例部分缓解，4例无效。药物治疗三个月后，30名女性接受了DTC治疗。该治疗后，21例患者的疣体消退。24个月后，仅使用IFN时复发率为37.9%，IFN与DTC联合使用时复发率为4.51%。
这些数据表明，尖锐湿疣的成功治疗方案是在疣体持续存在时采用IFN治疗并联合DTC。
