年龄对使用冷冻供体精子进行宫腔内人工授精的影响。

Effect of age on intrauterine insemination with frozen donor sperm.

作者信息

Kang B M, Wu T C

机构信息

Department of Obstetrics and Gynecology, UCLA School of Medicine, USA.

出版信息

Obstet Gynecol. 1996 Jul;88(1):93-8. doi: 10.1016/0029-7844(96)00074-9.

DOI:10.1016/0029-7844(96)00074-9

PMID:8684770

Abstract

OBJECTIVE

To assess the effect of variables that influence the pregnancy outcome of intrauterine insemination with frozen donor sperm.

METHODS

A retrospective analysis of 408 cycles of frozen donor sperm inseminations were studied. Cycle fecundity and cumulative probability of pregnancy were compared according to several variables.

RESULTS

The pregnancy rate was 13.5% per treatment cycle and 57.3% per patient. By life-table analysis, the cumulative probability of pregnancy was 75.6% after 12 cycle attempts, but there was a plateau after seven cycles. The cycle fecundity after the seventh cycle was 0.05, compared with 0.16 during the first seven cycles. Age had a profound impact on cycle fecundity. The cycle fecundity for women age 35 or less, 35-40, and over 40 years old were 0.2, 0.12, and 0.06, respectively. The cumulative probability of pregnancy after seven cycles for women 35 years or younger was 88%, compared with 65 and 42% in women 35-40 and over 40 years old, respectively. The number of motile sperm inseminated for pregnant cycles was higher than that for nonpregnant cycles. The fecundity rates for cycles with five or fewer, five to ten, greater than ten to 20, and over 20 million motile sperm inseminated were 5, 11, 16, and 20%, respectively.

CONCLUSION

The most significant predictors of the fertility of intrauterine insemination with frozen donor sperm were the women's age and the total number of motile sperm inseminated. Fecundity dropped after seven cycles of treatment.

摘要

目的

评估影响冷冻供精宫腔内人工授精妊娠结局的相关变量。

方法

对408个冷冻供精人工授精周期进行回顾性分析。根据多个变量比较周期受孕力和累积妊娠概率。

结果

每个治疗周期的妊娠率为13.5%，每位患者的妊娠率为57.3%。通过生命表分析，12个周期尝试后的累积妊娠概率为75.6%，但7个周期后出现平台期。第七个周期后的周期受孕力为0.05，而前七个周期为0.16。年龄对周期受孕力有深远影响。35岁及以下、35 - 40岁和40岁以上女性的周期受孕力分别为0.2、0.12和0.06。35岁及以下女性7个周期后的累积妊娠概率为88%，相比之下，35 - 40岁和40岁以上女性分别为65%和42%。妊娠周期所输入的活动精子数量高于未妊娠周期。输入活动精子数量为500万及以下、500万至1000万、1000万至2000万以及超过2000万的周期受孕率分别为5%、11%、16%和20%。