Chaubert P, Bouzourene H, Saraga E
Institut Universitaire de Pathologie, Lausanne, Switzerland.
Mod Pathol. 1996 Mar;9(3):189-93.
We examined immunohistochemically 50 gastric carcinomas from European patients for estrogen receptors, progesterone receptors, and hormone-receptor-related proteins pS2 and ERD5. Unlike gastric carcinomas from non-Europeans reported previously, the carcinomas of the present series were all negative for estrogen and progesterone receptors. One-half of them, however, expressed pS2, and three-fourths were positive for ERD5. pS2 expression was significantly more frequent in carcinomas of the diffuse type than in those of the intestinal type and in advanced carcinomas compared with early ones. Our results indicate that pS2 and ERD5 are estrogen independent in the stomach. The possibility that estrogen and progesterone receptor status could be different in gastric carcinomas from Occidental and non-Occidental patients is discussed.
我们采用免疫组织化学方法检测了50例欧洲患者的胃癌组织，以检测雌激素受体、孕激素受体以及与激素受体相关的蛋白pS2和ERD5。与先前报道的非欧洲人胃癌不同，本系列研究中的胃癌雌激素和孕激素受体均为阴性。然而，其中一半表达pS2，四分之三ERD5呈阳性。弥漫型胃癌中pS2表达明显高于肠型胃癌，进展期胃癌高于早期胃癌。我们的结果表明，胃中pS2和ERD5与雌激素无关。本文还讨论了西方和非西方患者胃癌中雌激素和孕激素受体状态可能存在差异的可能性。
