Homann C, Garred P, Graudal N A, Hasselqvist P, Christiansen M, Fagerhol M K, Thomsen A C
Medicinsk afdeling B, Bispebjerg Hospital, København.
Ugeskr Laeger. 1996 May 20;158(21):2980-4.
The purpose of this study was to determine plasma concentrations of calprotectin in patients with different severity of alcoholic cirrhosis. Additionally, the prognostic value of calprotectin for recurrent infections and for survival was investigated after a median observation period of 19 months. No difference was found in calprotectin levels when comparing healthy controls (n = 16), compensated (n = 50) and decompensated cirrhotics (n = 34). However, high calprotectin concentrations (> median) was a significant prognostic marker of poor survival (p = 0.001, Log-rank test). Calprotectin levels (> median) showed an independent and much higher prognostic value than variables of liver disease (multivariate Cox model). During follow-up calprotectin levels (> median) were also a predictor of recurrent infection (p = 0.009, Log-rank test). Thus, in patients with alcoholic cirrhosis, plasma calprotectin appears to be a new prognostic marker of survival, which seems independent of severity of liver disease. Furthermore, high plasma calprotectin levels may characterize a group of cirrhotics with recurring bacterial infections.
本研究的目的是测定不同严重程度酒精性肝硬化患者的血浆钙卫蛋白浓度。此外，在19个月的中位观察期后，研究了钙卫蛋白对反复感染和生存的预后价值。在比较健康对照者（n = 16）、代偿期（n = 50）和失代偿期肝硬化患者（n = 34）时，未发现钙卫蛋白水平存在差异。然而，高钙卫蛋白浓度（>中位数）是生存不良的显著预后标志物（p = 0.001，对数秩检验）。钙卫蛋白水平（>中位数）显示出比肝病变量更高的独立预后价值（多变量Cox模型）。在随访期间，钙卫蛋白水平（>中位数）也是反复感染的预测指标（p = 0.009，对数秩检验）。因此，在酒精性肝硬化患者中，血浆钙卫蛋白似乎是一种新的生存预后标志物，其似乎与肝病严重程度无关。此外，高血浆钙卫蛋白水平可能是一组反复发生细菌感染的肝硬化患者的特征。
