Kleinegger C L, Stoeckel D C, Kurago Z B
Department of Oral Pathology, Radiology and Medicine, University of Iowa College of Dentistry, Iowa City, Iowa 52240-1001, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jul;92(1):62-7. doi: 10.1067/moe.2001.115973.
The purpose of this study was to compare salivary calprotectin levels in subjects with oral candidiasis to the levels in healthy age- and sex-matched control subjects and to investigate the relationship of salivary calprotectin to intensity of oral candidal carriage and infection and to predisposing factors for candidiasis.
Using enzyme-linked immunosorbent assay, we measured calprotectin in unstimulated whole saliva collected from 22 subjects with oral candidiasis and in saliva collected from 22 control subjects. Calprotectin levels in the 2 groups were compared by using the Wilcoxon signed rank test. The relationships between calprotectin levels and Candida counts were assessed by using the Spearman rank correlation test. The nonparametric 1-way analysis of variance test was used to study the relationship between calprotectin levels and presence of non-albicans Candida and individual predisposing factors for candidiasis. The Kruskal-Wallis test was used to evaluate the relationship between calprotectin and predisposing factors in subjects grouped by total number of predisposing factors identified.
No relationship was found between calprotectin and individual or total number of predisposing factors. Higher calprotectin levels were found in subjects with candidiasis, and calprotectin concentration positively correlated with intensity of candidal infection.
These findings suggest that calprotectin production, or release, or both, may be increased in subjects with candidiasis.
本研究旨在比较口腔念珠菌病患者与年龄和性别匹配的健康对照者的唾液钙卫蛋白水平，并研究唾液钙卫蛋白与口腔念珠菌携带和感染强度以及念珠菌病易感因素之间的关系。
我们采用酶联免疫吸附测定法，测量了22名口腔念珠菌病患者未刺激的全唾液中的钙卫蛋白，以及22名对照者唾液中的钙卫蛋白。两组的钙卫蛋白水平采用Wilcoxon符号秩检验进行比较。钙卫蛋白水平与念珠菌计数之间的关系采用Spearman秩相关检验进行评估。非参数单因素方差分析用于研究钙卫蛋白水平与非白色念珠菌的存在以及念珠菌病个体易感因素之间的关系。Kruskal-Wallis检验用于评估按确定的易感因素总数分组的受试者中钙卫蛋白与易感因素之间的关系。
未发现钙卫蛋白与个体或易感因素总数之间存在关联。念珠菌病患者的钙卫蛋白水平较高，且钙卫蛋白浓度与念珠菌感染强度呈正相关。
这些发现表明，念珠菌病患者的钙卫蛋白产生、释放或两者可能会增加。
