Westergaard T, Frisch M, Melbye M
Center for epidemiologisk grundforskning, Statens Seruminstitut, København.
Ugeskr Laeger. 1996 May 27;158(22):3153-5.
Previous studies have suggested an excess cancer risk in patients with carcinoid tumours. We re-examined this association by the use of truly population-based data from the Danish Cancer Register. One thousand and twenty-nine patients with carcinoid tumours diagnosed in Denmark 1978-89 were identified and followed for the occurrence of subsequent cancers. The ratio of observed to expected cancers calculated from population rates served as a measure of the relative cancer risk (RR). The annual age-adjusted incidence rate for carcinoid tumours was 1.1 per 100,000 person-years (world standardized). The overall relative risk of subsequent cancers was 1.1 (95% CI 0.8-1.6). Thyroid cancer, tumours of the brain and nervous system and non-Hodgkin's lymphomas were in excess. Overall, this study does not support previous findings of a general excess cancer risk in patients with carcinoid tumors. Significantly increased risks of cancer were observed at some sites, but these findings were based on small numbers, and consequently need further confirmation.
既往研究提示类癌肿瘤患者存在额外的癌症风险。我们利用丹麦癌症登记处基于真实人群的数据重新审视了这种关联。识别出1978 - 1989年在丹麦诊断的1029例类癌肿瘤患者，并对其后续癌症的发生情况进行随访。根据人群发病率计算的观察到的癌症与预期癌症的比率作为相对癌症风险（RR）的衡量指标。类癌肿瘤的年龄调整后年发病率为每10万人年1.1例（世界标准化）。后续癌症的总体相对风险为1.1（95%可信区间0.8 - 1.6）。甲状腺癌、脑和神经系统肿瘤以及非霍奇金淋巴瘤的发病有所增加。总体而言，本研究不支持既往关于类癌肿瘤患者普遍存在额外癌症风险的研究结果。在某些部位观察到癌症风险显著增加，但这些发现基于小样本量，因此需要进一步证实。
