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病例报告:与播散性类圆线虫病相关的反应性噬血细胞综合征

Case report: reactive hemophagocytic syndrome associated with disseminated strongyloidiasis.

作者信息

Finkielman J D, Grinberg A R, Paz L A, Plana J L, Benchetrit G A, Nicastro M A, Roncoroni A J

机构信息

Instituto de Investigaciones Medicas "Alfredo Lanari", Universidad de Buenos Aires, Argentina.

出版信息

Am J Med Sci. 1996 Jul;312(1):37-9. doi: 10.1097/00000441-199607000-00008.

Abstract

The reactive hemophagocytic syndrome is a condition characterized by systemic proliferation of benign hemophagocytic histiocytes, fever, cytopenia, abnormal liver function, and frequently coagulopathy and hepatosplenomegaly. Its occurrence has been documented in association with viral, bacterial, fungal and parasitic infections; a wide spectrum of malignant neoplasms; some miscellaneous disorders; and phenytoin. Disseminated strongyloidiasis is reported in a patients with systemic lupus erythematosus treated with corticosteroids in whom a reactive hemophagocytic syndrome developed and who finally died. This reactive hemophagocytic syndrome is reported for the first time in strongyloidiasis and may not have been recognized in former patients.

摘要

反应性噬血细胞综合征是一种以良性噬血细胞组织细胞系统性增殖、发热、血细胞减少、肝功能异常以及常伴有凝血病和肝脾肿大为特征的病症。其发生与病毒、细菌、真菌和寄生虫感染;多种恶性肿瘤;一些杂症;以及苯妥英有关。据报道,一名接受皮质类固醇治疗的系统性红斑狼疮患者发生了反应性噬血细胞综合征并最终死亡,该患者同时患有播散性类圆线虫病。这种反应性噬血细胞综合征在类圆线虫病中首次报道,以往患者中可能未被认识到。

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